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Cardiac magnetic resonance imaging-derived pulmonary artery distensibility index correlates with pulmonary artery stiffness and predicts functional capacity in patients with pulmonary arterial hypertension

Authors
 Ki-Woon Kang  ;  Hyuk-Jae Chang  ;  Young-Jin Kim  ;  Byoung-Wook Choi  ;  Hye Sun Lee  ;  Woo-In Yang  ;  Chi-Young Shim  ;  Jongwon Ha  ;  Namsik Chung 
Citation
 CIRCULATION JOURNAL, Vol.75(9) : 2244-2251, 2011 
Journal Title
 CIRCULATION JOURNAL 
ISSN
 1346-9843 
Issue Date
2011
MeSH
Adult ; Cardiac Catheterization ; Familial Primary Pulmonary Hypertension ; Female ; Humans ; Hypertension, Pulmonary/diagnostic imaging* ; Hypertension, Pulmonary/physiopathology* ; Magnetic Resonance Angiography/methods* ; Male ; Middle Aged ; Pulmonary Artery/diagnostic imaging* ; Pulmonary Artery/physiopathology* ; Radiography ; Vascular Resistance*
Abstract
BACKGROUND: Increased stiffness of the pulmonary vascular bed is known to increase mortality in patients with pulmonary arterial hypertension (PAH); and pulmonary artery (PA) stiffness is also thought to be associated with exercise capacity. The purpose of the present study was to investigate whether cardiac magnetic resonance imaging (CMRI)-derived PA distensibility index correlates with PA stiffness estimated on right heart catheterization (RHC) and predicts functional capacity (FC) in patients with PAH. METHODS AND RESULTS: Thirty-five consecutive PAH patients (23% male, mean age, 44 ± 13 years; 69% idiopathic) underwent CMRI, RHC, and 6-min walk test (6MWT). PA distensibility indices were derived from cross-sectional area change (%) in the transverse view, perpendicular to the axis of the main PA, on CMRI [(maximum area-minimum area)/minimum area during cardiac cycle]. Among the PA stiffness indices, pulmonary vascular resistance (PVR) and PA capacitance were calculated using hemodynamic dataset from RHC. CMRI-derived PA distensibility was inversely correlated with PVR (R²=0.34, P<0.001) and directly correlated with PA capacitance (R²=0.35, P<0.001), and the distance in the 6MWT (R²=0.61, P<0.001). Furthermore, PA distensibility <20% predicted poor FC (<400m in 6MWT) with a sensitivity of 82% and a specificity of 94%. CONCLUSIONS: Non-invasive CMRI-derived PA distensibility index correlates with PA stiffness and can predict FC in patients with PAH.
Files in This Item:
T201103061.pdf Download
DOI
10.1253/circj.CJ-10-1310
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ki Woon(강기운)
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Yang, Woo In(양우인)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Chung, Nam Sik(정남식)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93849
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