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Cardiac magnetic resonance imaging-derived pulmonary artery distensibility index correlates with pulmonary artery stiffness and predicts functional capacity in patients with pulmonary arterial hypertension

Authors
 Ki-Woon Kang  ;  Hyuk-Jae Chang  ;  Young-Jin Kim  ;  Byoung-Wook Choi  ;  Hye Sun Lee  ;  Woo-In Yang  ;  Chi-Young Shim  ;  Jongwon Ha  ;  Namsik Chung 
Citation
 Circulation Journal, Vol.75(9) : 2244-2251, 2011 
Journal Title
 Circulation Journal 
ISSN
 1346-9843 
Issue Date
2011
Abstract
BACKGROUND: Increased stiffness of the pulmonary vascular bed is known to increase mortality in patients with pulmonary arterial hypertension (PAH); and pulmonary artery (PA) stiffness is also thought to be associated with exercise capacity. The purpose of the present study was to investigate whether cardiac magnetic resonance imaging (CMRI)-derived PA distensibility index correlates with PA stiffness estimated on right heart catheterization (RHC) and predicts functional capacity (FC) in patients with PAH. METHODS AND RESULTS: Thirty-five consecutive PAH patients (23% male, mean age, 44 ± 13 years; 69% idiopathic) underwent CMRI, RHC, and 6-min walk test (6MWT). PA distensibility indices were derived from cross-sectional area change (%) in the transverse view, perpendicular to the axis of the main PA, on CMRI [(maximum area-minimum area)/minimum area during cardiac cycle]. Among the PA stiffness indices, pulmonary vascular resistance (PVR) and PA capacitance were calculated using hemodynamic dataset from RHC. CMRI-derived PA distensibility was inversely correlated with PVR (R²=0.34, P<0.001) and directly correlated with PA capacitance (R²=0.35, P<0.001), and the distance in the 6MWT (R²=0.61, P<0.001). Furthermore, PA distensibility <20% predicted poor FC (<400m in 6MWT) with a sensitivity of 82% and a specificity of 94%. CONCLUSIONS: Non-invasive CMRI-derived PA distensibility index correlates with PA stiffness and can predict FC in patients with PAH.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93849
DOI
10.1253/circj.CJ-10-1310
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
강기운(Kang, Ki Woon) ; 심지영(Shim, Chi Young) ; 양우인(Yang, Woo In) ; 이혜선(Lee, Hye Sun) ; 장혁재(Chang, Hyuck Jae) ; 정남식(Chung, Nam Sik) ; 최병욱(Choi, Byoung Wook) ; 하종원(Ha, Jong Won)
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