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Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor

 Liwen Li  ;  Hyuk-Jae Kwon  ;  Hidemitsu Harada  ;  Hayato Ohshima  ;  Sung-Won Cho  ;  Han-Sung Jung 
 GENE EXPRESSION PATTERNS, Vol.11(3-4) : 163-170, 2011 
Journal Title
Issue Date
ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; ATP-Binding Cassette Transporters/genetics* ; ATP-Binding Cassette Transporters/metabolism ; Adaptor Proteins, Signal Transducing/genetics* ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Antigens, Differentiation/metabolism ; Dental Papilla/embryology ; Dental Papilla/growth & development ; Dental Papilla/metabolism ; Embryonic Stem Cells/metabolism ; Epithelium/embryology ; Epithelium/growth & development ; Epithelium/metabolism ; Female ; Gene Expression Regulation, Developmental ; Incisor/embryology* ; Incisor/growth & development* ; Incisor/metabolism ; Mice ; Mice, Inbred ICR ; Nuclear Proteins/genetics* ; Nuclear Proteins/metabolism ; Octamer Transcription Factor-3/genetics* ; Octamer Transcription Factor-3/metabolism ; Phosphoproteins/genetics* ; Phosphoproteins/metabolism ; Polycomb Repressive Complex 1 ; Proto-Oncogene Proteins/genetics* ; Proto-Oncogene Proteins/metabolism ; Repressor Proteins/genetics* ; Repressor Proteins/metabolism
ABCG2 ; Bmi-1 ; Oct-3/4 ; Yap ; Incisor ; Tooth development
Recent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuk Jae(권혁제)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
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