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Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor

DC Field Value Language
dc.contributor.author권혁제-
dc.contributor.author정한성-
dc.contributor.author조성원-
dc.date.accessioned2014-12-20T16:29:12Z-
dc.date.available2014-12-20T16:29:12Z-
dc.date.issued2011-
dc.identifier.issn1567-133X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92806-
dc.description.abstractRecent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor.-
dc.description.statementOfResponsibilityopen-
dc.format.extent163~170-
dc.relation.isPartOfGENE EXPRESSION PATTERNS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHATP Binding Cassette Transporter, Sub-Family G, Member 2-
dc.subject.MESHATP-Binding Cassette Transporters/genetics*-
dc.subject.MESHATP-Binding Cassette Transporters/metabolism-
dc.subject.MESHAdaptor Proteins, Signal Transducing/genetics*-
dc.subject.MESHAdaptor Proteins, Signal Transducing/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Differentiation/metabolism-
dc.subject.MESHDental Papilla/embryology-
dc.subject.MESHDental Papilla/growth & development-
dc.subject.MESHDental Papilla/metabolism-
dc.subject.MESHEmbryonic Stem Cells/metabolism-
dc.subject.MESHEpithelium/embryology-
dc.subject.MESHEpithelium/growth & development-
dc.subject.MESHEpithelium/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Developmental-
dc.subject.MESHIncisor/embryology*-
dc.subject.MESHIncisor/growth & development*-
dc.subject.MESHIncisor/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHNuclear Proteins/genetics*-
dc.subject.MESHNuclear Proteins/metabolism-
dc.subject.MESHOctamer Transcription Factor-3/genetics*-
dc.subject.MESHOctamer Transcription Factor-3/metabolism-
dc.subject.MESHPhosphoproteins/genetics*-
dc.subject.MESHPhosphoproteins/metabolism-
dc.subject.MESHPolycomb Repressive Complex 1-
dc.subject.MESHProto-Oncogene Proteins/genetics*-
dc.subject.MESHProto-Oncogene Proteins/metabolism-
dc.subject.MESHRepressor Proteins/genetics*-
dc.subject.MESHRepressor Proteins/metabolism-
dc.titleExpression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorLiwen Li-
dc.contributor.googleauthorHyuk-Jae Kwon-
dc.contributor.googleauthorHidemitsu Harada-
dc.contributor.googleauthorHayato Ohshima-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1016/j.gep.2010.11.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00261-
dc.contributor.localIdA03758-
dc.contributor.localIdA03837-
dc.relation.journalcodeJ00923-
dc.identifier.eissn1872-7298-
dc.identifier.pmid21073982-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1567133X1000116X-
dc.subject.keywordABCG2-
dc.subject.keywordBmi-1-
dc.subject.keywordOct-3/4-
dc.subject.keywordYap-
dc.subject.keywordIncisor-
dc.subject.keywordTooth development-
dc.contributor.alternativeNameKwon, Hyuk Jae-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthorKwon, Hyuk Jae-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.rights.accessRightsnot free-
dc.citation.volume11-
dc.citation.number3-4-
dc.citation.startPage163-
dc.citation.endPage170-
dc.identifier.bibliographicCitationGENE EXPRESSION PATTERNS, Vol.11(3-4) : 163-170, 2011-
dc.identifier.rimsid28769-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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