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Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy

Authors
 Eun-Kyung Lim  ;  Warayuth Sajomsang  ;  Yuna Choi  ;  Eunji Jang  ;  Hwunjae Lee  ;  Byunghoon Kang  ;  Eunjung Kim  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Sang Jeon Chung  ;  Yong-Min Huh 
Citation
 NANOSCALE RESEARCH LETTERS, Vol.8(1) : 467, 2013 
Journal Title
 NANOSCALE RESEARCH LETTERS 
ISSN
 1931-7573 
Issue Date
2013
Keywords
Theragnosis ; Cancer therapy ; Drug delivery ; pH-sensitive ; Magnetic resonance imaging ; Nanocomposites
Abstract
Smart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-DMNPs), were developed in this study. NChitosan-DMNPs are capable of pH-sensitive drug release with MR-guided images because doxorubicin (DOX) and magnetic nanocrystals (MNCs) are encapsulated into the designed N-naphthyl-O-dimethymaleoyl chitosan (N-nap-O-MalCS). This system exhibits rapid DOX release as acidity increases, high stability under high pH conditions, and sufficient capacity for diagnosing and monitoring therapeutic responses. These results demonstrate that NChitosan-DMNPs have potential as theragnosis nanocomposites for effective cancer therapy.
Files in This Item:
T201304484.pdf Download
DOI
10.1186/1556-276X-8-467
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lee, Hwun Jae(이훈재)
Lim, Eun Kyung(임은경)
Choi, Yu Na(최유나)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88685
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