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Cited 45 times in

Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy

DC Field Value Language
dc.contributor.author허용민-
dc.contributor.author서진석-
dc.contributor.author이훈재-
dc.contributor.author임은경-
dc.contributor.author최유나-
dc.date.accessioned2014-12-18T09:42:48Z-
dc.date.available2014-12-18T09:42:48Z-
dc.date.issued2013-
dc.identifier.issn1931-7573-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88685-
dc.description.abstractSmart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-DMNPs), were developed in this study. NChitosan-DMNPs are capable of pH-sensitive drug release with MR-guided images because doxorubicin (DOX) and magnetic nanocrystals (MNCs) are encapsulated into the designed N-naphthyl-O-dimethymaleoyl chitosan (N-nap-O-MalCS). This system exhibits rapid DOX release as acidity increases, high stability under high pH conditions, and sufficient capacity for diagnosing and monitoring therapeutic responses. These results demonstrate that NChitosan-DMNPs have potential as theragnosis nanocomposites for effective cancer therapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNANOSCALE RESEARCH LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleChitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun-Kyung Lim-
dc.contributor.googleauthorWarayuth Sajomsang-
dc.contributor.googleauthorYuna Choi-
dc.contributor.googleauthorEunji Jang-
dc.contributor.googleauthorHwunjae Lee-
dc.contributor.googleauthorByunghoon Kang-
dc.contributor.googleauthorEunjung Kim-
dc.contributor.googleauthorSeungjoo Haam-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorSang Jeon Chung-
dc.contributor.googleauthorYong-Min Huh-
dc.identifier.doi10.1186/1556-276X-8-467-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04359-
dc.contributor.localIdA01916-
dc.contributor.localIdA03346-
dc.contributor.localIdA03391-
dc.contributor.localIdA04130-
dc.relation.journalcodeJ02286-
dc.identifier.eissn1556-276X-
dc.identifier.pmid24206754-
dc.subject.keywordTheragnosis-
dc.subject.keywordCancer therapy-
dc.subject.keywordDrug delivery-
dc.subject.keywordpH-sensitive-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordNanocomposites-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameLee, Hwun Jae-
dc.contributor.alternativeNameLim, Eun Kyung-
dc.contributor.alternativeNameChoi, Yu Na-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorLee, Hwun Jae-
dc.contributor.affiliatedAuthorLim, Eun Kyung-
dc.contributor.affiliatedAuthorChoi, Yu Na-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage467-
dc.identifier.bibliographicCitationNANOSCALE RESEARCH LETTERS, Vol.8(1) : 467, 2013-
dc.identifier.rimsid33408-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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