0 160

Cited 0 times in

Prediction of systemic biomarkers from retinal photographs: development and validation of deep-learning algorithms

Authors
 Rim, Tyler Hyungtaek  ;  Lee, Geunyoung  ;  Kim, Youngnam  ;  Tham, Yih-Chung  ;  Lee, Chan Joo  ;  Baik, Su Jung  ;  Kim, Yong Ah  ;  Yu, Marco  ;  Deshmukh, Mihir  ;  Lee, Byoung Kwon  ;  Park, Sungha  ;  Kim, Hyeon Chang  ;  Sabayanagam, Charumathi  ;  Ting, Daniel S. W.  ;  Wang, Ya Xing  ;  Jonas, Jost B.  ;  Kim, Sung Soo  ;  Wong, Tien Yin  ;  Cheng, Ching-Yu 
Citation
 LANCET DIGITAL HEALTH, Vol.2(10) : E526-E536, 2020-10 
Journal Title
LANCET DIGITAL HEALTH
Issue Date
2020-10
Abstract
Background The application of deep learning to retinal photographs has yielded promising results in predicting age, sex, blood pressure, and haematological parameters. However, the broader applicability of retinal photograph-based deep learning for predicting other systemic biomarkers and the generalisability of this approach to various populations remains unexplored. Methods With use of 236 257 retinal photographs from seven diverse Asian and European cohorts (two health screening centres in South Korea, the Beijing Eye Study, three cohorts in the Singapore Epidemiology of Eye Diseases study, and the UK Biobank), we evaluated the capacities of 47 deep-learning algorithms to predict 47 systemic biomarkers as outcome variables, including demographic factors (age and sex); body composition measurements; blood pressure; haematological parameters; lipid profiles; biochemical measures; biomarkers related to liver function, thyroid function, kidney function, and inflammation; and diabetes. The standard neural network architecture of VGG16 was adopted for model development. Findings In addition to previously reported systemic biomarkers, we showed quantification of body composition indices (muscle mass, height, and bodyweight) and creatinine from retinal photographs. Body muscle mass could be predicted with an R-2 of 0.52 (95% CI 0.51-0.53) in the internal test set, and of 0.33 (0.30-0.35) in one external test set with muscle mass measurement available. The R-2 value for the prediction of height was 0.42 (0.40-0.43), of bodyweight was 0.36 (0.34-0.37), and of creatinine was 0.38 (0.37-0.40) in the internal test set. However, the performances were poorer in external test sets (with the lowest performance in the European cohort), with R-2 values ranging between 0.08 and 0.28 for height, 0.04 and 0.19 for bodyweight, and 0.01 and 0.26 for creatinine. Of the 47 systemic biomarkers, 37 could not be predicted well from retinal photographs via deep learning (R-2=0.14 across all external test sets). Interpretation Our work provides new insights into the potential use of retinal photographs to predict systemic biomarkers, including body composition indices and serum creatinine, using deep learning in populations with a similar ethnic background. Further evaluations are warranted to validate these findings and evaluate the clinical utility of these algorithms.
Full Text
https://www.sciencedirect.com/science/article/pii/S2589750020302168
DOI
10.1016/S2589-7500(20)30216-8
Appears in Collections:
6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Young Ah(김영아)
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
Rim, Tyler Hyungtaek(임형택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181808
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links