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Dysmobility syndrome is associated with prevalent morphometric vertebral fracture in older adults: the Korean Urban-Rural Elderly (KURE) study.

Authors
 Namki Hong  ;  Chang Oh Kim  ;  Yoosik Youm  ;  Jin-Young Choi  ;  Hyeon Chang Kim  ;  Yumie Rhee 
Citation
 Archives of Osteoporosis, Vol.13 : 86, 2018 
Journal Title
 Archives of Osteoporosis 
ISSN
 1862-3522 
Issue Date
2018
Keywords
Dysmobility syndrome ; Falls ; Obesity ; Osteoporosis ; Sarcopenia
Abstract
In a community-dwelling elderly cohort, dysmobility syndrome was associated with elevated odds of morphometric vertebral fracture or any prevalent fracture, independent of age and covariates. Dysmobility syndrome improved discrimination for fracture when added to the FRAX score. INTRODUCTION: Dysmobility syndrome was coined to indicate patients with impaired musculoskeletal health. Data on the association of dysmobility syndrome with prevalent morphometric vertebral fracture (VF) in elderly persons are limited. METHODS: A total of 1369 community-dwelling elderly subjects (mean age 71.6 years; women 66%) were analyzed. Dysmobility syndrome was defined as ≥ 3 components among falls, low lean mass, high fat mass, osteoporosis, low grip strength, and low timed get-up-and-go performance. VF was defined as a ≥ 25% reduction in the height of vertebral bodies in plain radiographs. Modified cutpoints of each component at which elevate the odds of fracture were investigated using receiver-operating characteristics analysis. Net reclassification improvement (NRI) and integrated discrimination index (IDI) were calculated to assess additive discriminatory value of dysmobility syndrome over FRAX. RESULTS: The prevalence of VF and any fracture composite of VF and non-VF was 16% and 25%, respectively, increasing according to number of dysmobility components (from 0 to 5; VF 10-35%; any fracture 16-45%). Dysmobility syndrome was associated with elevated odds of VF (adjusted OR [aOR] 1.52, 95% CI 1.08-2.15) or any fracture (aOR 1.46, 95% CI 1.07-1.98) but no longer with non-VF (aOR 1.31, 95% CI 0.86-1.98) in multivariate model, whereas modified definition showed robust association with non-VF (aOR 1.79, 95% CI 1.23-2.60). Dysmobility syndrome improved discrimination for prevalent fracture when added to FRAX (NRI 0.25, 95% CI 0.13-0.37; IDI 0.020, 95% CI 0.014-0.026). CONCLUSIONS: Dysmobility syndrome was associated with elevated odds of morphometric VF in community-dwelling older adults, independent of age and covariates.
DOI
10.1007/s11657-018-0500-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
최진영(Choi, Jin Young) ORCID logo https://orcid.org/0000-0002-9025-6274
홍남기(Hong, Nam Ki) ORCID logo https://orcid.org/0000-0002-8246-1956
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163205
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