0 781

Cited 11 times in

Dysmobility syndrome is associated with prevalent morphometric vertebral fracture in older adults: the Korean Urban-Rural Elderly (KURE) study.

DC Field Value Language
dc.contributor.author김창오-
dc.contributor.author김현창-
dc.contributor.author이유미-
dc.contributor.author최진영-
dc.contributor.author홍남기-
dc.date.accessioned2018-09-28T08:53:55Z-
dc.date.available2018-09-28T08:53:55Z-
dc.date.issued2018-
dc.identifier.issn1862-3522-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163205-
dc.description.abstractIn a community-dwelling elderly cohort, dysmobility syndrome was associated with elevated odds of morphometric vertebral fracture or any prevalent fracture, independent of age and covariates. Dysmobility syndrome improved discrimination for fracture when added to the FRAX score. INTRODUCTION: Dysmobility syndrome was coined to indicate patients with impaired musculoskeletal health. Data on the association of dysmobility syndrome with prevalent morphometric vertebral fracture (VF) in elderly persons are limited. METHODS: A total of 1369 community-dwelling elderly subjects (mean age 71.6 years; women 66%) were analyzed. Dysmobility syndrome was defined as ≥ 3 components among falls, low lean mass, high fat mass, osteoporosis, low grip strength, and low timed get-up-and-go performance. VF was defined as a ≥ 25% reduction in the height of vertebral bodies in plain radiographs. Modified cutpoints of each component at which elevate the odds of fracture were investigated using receiver-operating characteristics analysis. Net reclassification improvement (NRI) and integrated discrimination index (IDI) were calculated to assess additive discriminatory value of dysmobility syndrome over FRAX. RESULTS: The prevalence of VF and any fracture composite of VF and non-VF was 16% and 25%, respectively, increasing according to number of dysmobility components (from 0 to 5; VF 10-35%; any fracture 16-45%). Dysmobility syndrome was associated with elevated odds of VF (adjusted OR [aOR] 1.52, 95% CI 1.08-2.15) or any fracture (aOR 1.46, 95% CI 1.07-1.98) but no longer with non-VF (aOR 1.31, 95% CI 0.86-1.98) in multivariate model, whereas modified definition showed robust association with non-VF (aOR 1.79, 95% CI 1.23-2.60). Dysmobility syndrome improved discrimination for prevalent fracture when added to FRAX (NRI 0.25, 95% CI 0.13-0.37; IDI 0.020, 95% CI 0.014-0.026). CONCLUSIONS: Dysmobility syndrome was associated with elevated odds of morphometric VF in community-dwelling older adults, independent of age and covariates.-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfARCHIVES OF OSTEOPOROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDysmobility syndrome is associated with prevalent morphometric vertebral fracture in older adults: the Korean Urban-Rural Elderly (KURE) study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorYoosik Youm-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorYumie Rhee-
dc.identifier.doi10.1007/s11657-018-0500-2-
dc.contributor.localIdA01044-
dc.contributor.localIdA01142-
dc.contributor.localIdA03012-
dc.contributor.localIdA04200-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ03447-
dc.identifier.eissn1862-3514-
dc.identifier.pmid30109432-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s11657-018-0500-2-
dc.subject.keywordDysmobility syndrome-
dc.subject.keywordFalls-
dc.subject.keywordObesity-
dc.subject.keywordOsteoporosis-
dc.subject.keywordSarcopenia-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameChoi, Jin Young-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorChoi, Jin Young-
dc.contributor.affiliatedAuthorHong, Namki-
dc.citation.volume13-
dc.citation.startPage86-
dc.identifier.bibliographicCitationARCHIVES OF OSTEOPOROSIS, Vol.13 : 86, 2018-
dc.identifier.rimsid58472-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.