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Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men

Authors
 Jung Eun Lee  ;  Yong Jae Lee  ;  Soo Yoon Chung  ;  Hee Woo Cho  ;  Byoung Jin Park  ;  Dong Hyuk Jung 
Citation
 PLoS One, Vol.13(3) : e0193191, 2018 
Journal Title
 PLoS One 
Issue Date
2018
MeSH
Adult ; Asian Continental Ancestry Group ; *Coronary Artery Disease/diagnostic imaging/epidemiology/etiology ; Humans ; *Intracranial Arteriosclerosis/diagnostic imaging/epidemiology/etiology ; Male ; Middle Aged ; *Multidetector Computed Tomography ; *Non-alcoholic Fatty Liver Disease/complications/diagnostic imaging/epidemiology ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; *Severity of Illness Index ; Ultrasonography
Abstract
BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution-magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20-70 years. RESULTS: A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054-1.081, p < 0.001), body mass index (OR 1.120; 1.08 0-1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001-1.023, p = 0.027; OR 1.006; 1.001-1.012, p = 0.036), fasting glucose (OR 1.021; 1.015-1.027, p < 0.001), triglycerides (OR 1.002; 1.000-1.003, p = 0.016), hypertension (OR 2.836; 2.268-3.546, p < 0.001), and diabetes (OR 2.911; 2.137-3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965-0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89). CONCLUSIONS: Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA.
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DOI
10.1371/journal.pone.0193191
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
Chung, Soo Yoon(정수윤) ORCID logo https://orcid.org/0000-0002-6751-7288
Cho, Hee Woo(조희우) ORCID logo https://orcid.org/0000-0002-5079-6954
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162288
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