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Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men

 Jung Eun Lee  ;  Yong Jae Lee  ;  Soo Yoon Chung  ;  Hee Woo Cho  ;  Byoung Jin Park  ;  Dong Hyuk Jung 
 PLoS One, Vol.13(3) : e0193191, 2018 
Journal Title
 PLoS One 
Issue Date
Adult ; Asian Continental Ancestry Group ; *Coronary Artery Disease/diagnostic imaging/epidemiology/etiology ; Humans ; *Intracranial Arteriosclerosis/diagnostic imaging/epidemiology/etiology ; Male ; Middle Aged ; *Multidetector Computed Tomography ; *Non-alcoholic Fatty Liver Disease/complications/diagnostic imaging/epidemiology ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; *Severity of Illness Index ; Ultrasonography
BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution-magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20-70 years. RESULTS: A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054-1.081, p < 0.001), body mass index (OR 1.120; 1.08 0-1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001-1.023, p = 0.027; OR 1.006; 1.001-1.012, p = 0.036), fasting glucose (OR 1.021; 1.015-1.027, p < 0.001), triglycerides (OR 1.002; 1.000-1.003, p = 0.016), hypertension (OR 2.836; 2.268-3.546, p < 0.001), and diabetes (OR 2.911; 2.137-3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965-0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89). CONCLUSIONS: Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
이정은(Lee, Jung Eun) ORCID logo https://orcid.org/0000-0003-0917-2872
정동혁(Jung, Dong Hyuk) ORCID logo https://orcid.org/0000-0002-3411-0676
정수윤(Chung, Soo Yoon) ORCID logo https://orcid.org/0000-0002-6751-7288
조희우(Cho, Hee Woo) ORCID logo https://orcid.org/0000-0002-5079-6954
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