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Long-Term Follow-Up of Patients After Autologous Bone Marrow Cell Infusion for Decompensated Liver Cirrhosis

Authors
 Ja Kyung Kim  ;  Soo-Jeong Kim  ;  Yuri Kim  ;  Yong Eun Chung  ;  Young Nyun Park  ;  Hyun Ok Kim  ;  Jin Seok Kim  ;  Mi-Suk Park  ;  Isao Sakaida  ;  Do Young Kim  ;  Jung Il Lee  ;  Sang Hoon Ahn  ;  Kwan Sik Lee  ;  Kwang-Hyub Han 
Citation
 Cell Transplantation, Vol.26(6) : 1059-1066, 2017 
Journal Title
 Cell Transplantation 
ISSN
 0963-6897 
Issue Date
2017
MeSH
Adolescent ; Adult ; Adult Stem Cells/cytology ; Adult Stem Cells/physiology ; Aged ; Bone Marrow Cells/cytology* ; Bone Marrow Cells/physiology ; Bone Marrow Transplantation/methods ; Humans ; Liver/cytology ; Liver/pathology ; Liver Cirrhosis/therapy* ; Liver Regeneration/physiology ; Middle Aged ; Transplantation, Autologous/methods* ; Young Adult
Abstract
Although several human clinical trials using various bone marrow-derived cell types for cirrhotic or decompensated patients have reported a short-term benefit, long-term follow-up data are limited. We analyzed the long-term clinical outcomes of autologous bone marrow cell infusion (ABMI) for decompensated liver cirrhosis (LC). Patients enrolled in a pilot single-armed ABMI study were followed up more than 5 years. Bone marrow-derived mononuclear cells (BM-MNCs) from decompensated LC were harvested and after processing were infused into a peripheral vein. The laboratory test results and long-term clinical course including liver transplantation (LT), development of cancer, cause of death, and survival after ABMI were analyzed. Nineteen patients were followed up for a median of 66 months after ABMI. Liver function, including serum levels of albumin and Child-Pugh (CP) score, was improved at the 1-year follow-up. Liver volume was significantly greater, cirrhosis was sustained, and collagen content was decreased at the 6-month follow-up. Five years after ABMI, five patients (26.3%) maintained CP class A without LT or death, and five patients (26.3%) had undergone elective LT. Hepatocellular carcinoma (HCC) occurred in five patients (26.3%), and lymphoma and colon cancer occurred in one patient each. Three patients (15.8%) were lost to follow-up at months 22, 31, and 33, respectively, but maintained CP class A until their last follow-up. Five patients expired due to infection. While improved liver function was maintained in some patients for more than 5 years after ABMI, other patients developed HCC. Further studies of long-term follow-up cohorts after cell therapy for LC are warranted.
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T201703060.pdf Download
DOI
10.3727/096368917X694778
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김도영(Kim, Do Young)
김수정(Kim, Soo Jeong) ORCID logo https://orcid.org/0000-0001-8859-3573
김유리(Kim, Yu Ri) ORCID logo https://orcid.org/0000-0001-5505-0142
김자경(Kim, Ja Kyung) ORCID logo https://orcid.org/0000-0001-5025-6846
김진석(Kim, Jin Seok) ORCID logo https://orcid.org/0000-0001-8986-8436
김현옥(Kim, Hyun Ok) ORCID logo https://orcid.org/0000-0002-4964-1963
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
박영년(Park, Young Nyun) ORCID logo https://orcid.org/0000-0003-0357-7967
안상훈(Ahn, Sang Hoon) ORCID logo https://orcid.org/0000-0002-3629-4624
이관식(Lee, Kwan Sik) ORCID logo https://orcid.org/0000-0002-3672-1198
이정일(Lee, Jung Il) ORCID logo https://orcid.org/0000-0002-0142-1398
정용은(Chung, Yong Eun) ORCID logo https://orcid.org/0000-0003-0811-9578
한광협(Han, Kwang-Hyub) ORCID logo https://orcid.org/0000-0003-3960-6539
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160694
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