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Mean Platelet Volume to Platelet Count Ratio as a Promising Predictor of Early Mortality in Severe Sepsis

 Geun Ho Oh  ;  Sung Phil Chung  ;  Yoo Seok Park  ;  Jung Hwa Hong  ;  Hye Sun Lee  ;  Hyun Soo Chung  ;  Je Sung You  ;  Jong Woo Park  ;  Incheol Park 
 Shock, Vol.47(3) : 323-330, 2017 
Journal Title
Issue Date
Adult ; Aged ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Male ; Mean Platelet Volume/methods* ; Middle Aged ; Platelet Count/methods* ; Proportional Hazards Models ; Retrospective Studies ; Sepsis/diagnosis* ; Sepsis/mortality*
Mean platelet volume ; mortality ; platelet ; predictor ; sepsis ; shock
PURPOSE: We evaluated the mean platelet volume (MPV) to platelet ratio to determine its significance as a prognostic marker for early mortality in critically ill patients with suspected sepsis receiving early goal-directed therapy (EGDT). METHODS: We retrospectively reviewed the records from a prospective EGDT registry and screened eligible adult patients who were admitted to the emergency department (ED) with severe sepsis and/or septic shock. The MPV/platelet ratio was estimated as the MPV value divided by the platelet count on each day of hospitalization. The clinical outcome was 28-day mortality. RESULTS: We included 120 patients receiving EGDT. In the multivariate Cox proportional hazard models, higher MPV/platelet ratios on admission (HR: 1.04; 95% CI: 1.015-1.066; P = 0.002) and at 24 h (HR: 1.032; 95% CI: 1.012-1.054; P = 0.002) were significant risk factors for mortality at 28 days. An increased trend for 28-day mortality was associated with a MPV/platelet ratio >3.71 on admission (HR: 4.274; 95% CI: 1.228-14.874; P = 0.023) and a higher MPV/platelet ratio (>6.49) at 24 h (HR: 2.719; 95% CI: 1.048-7.051; P = 0.04) in patients with severe sepsis receiving EGDT. CONCLUSION: In our study, MPV or platelet count alone did not predict shock and 28-day mortality in patients with severe sepsis receiving EGDT. However, the MPV/platelet ratio at ED admission and on day 1 is a promising prognostic marker for 28-day mortality in patients with severe sepsis.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
박유석(Park, Yoo Seok) ORCID logo https://orcid.org/0000-0003-1543-4664
박인철(Park, In Cheol) ORCID logo https://orcid.org/0000-0001-7033-766X
오근호(Oh, Geun Ho)
유제성(You, Je Sung) ORCID logo https://orcid.org/0000-0002-2074-6745
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
정성필(Chung, Sung Pil) ORCID logo https://orcid.org/0000-0002-3074-011X
정현수(Chung, Hyun Soo) ORCID logo https://orcid.org/0000-0001-6110-1495
홍정화(Hong, Jung Hwa)
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