Cited 61 times in
Mean Platelet Volume to Platelet Count Ratio as a Promising Predictor of Early Mortality in Severe Sepsis
DC Field | Value | Language |
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dc.contributor.author | 박유석 | - |
dc.contributor.author | 정현수 | - |
dc.contributor.author | 홍정화 | - |
dc.contributor.author | 오근호 | - |
dc.contributor.author | 박인철 | - |
dc.contributor.author | 유제성 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정성필 | - |
dc.date.accessioned | 2017-11-01T08:46:04Z | - |
dc.date.available | 2017-11-01T08:46:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1073-2322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153615 | - |
dc.description.abstract | PURPOSE: We evaluated the mean platelet volume (MPV) to platelet ratio to determine its significance as a prognostic marker for early mortality in critically ill patients with suspected sepsis receiving early goal-directed therapy (EGDT). METHODS: We retrospectively reviewed the records from a prospective EGDT registry and screened eligible adult patients who were admitted to the emergency department (ED) with severe sepsis and/or septic shock. The MPV/platelet ratio was estimated as the MPV value divided by the platelet count on each day of hospitalization. The clinical outcome was 28-day mortality. RESULTS: We included 120 patients receiving EGDT. In the multivariate Cox proportional hazard models, higher MPV/platelet ratios on admission (HR: 1.04; 95% CI: 1.015-1.066; P = 0.002) and at 24 h (HR: 1.032; 95% CI: 1.012-1.054; P = 0.002) were significant risk factors for mortality at 28 days. An increased trend for 28-day mortality was associated with a MPV/platelet ratio >3.71 on admission (HR: 4.274; 95% CI: 1.228-14.874; P = 0.023) and a higher MPV/platelet ratio (>6.49) at 24 h (HR: 2.719; 95% CI: 1.048-7.051; P = 0.04) in patients with severe sepsis receiving EGDT. CONCLUSION: In our study, MPV or platelet count alone did not predict shock and 28-day mortality in patients with severe sepsis receiving EGDT. However, the MPV/platelet ratio at ED admission and on day 1 is a promising prognostic marker for 28-day mortality in patients with severe sepsis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | SHOCK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Emergency Service, Hospital/statistics & numerical data | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mean Platelet Volume/methods* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Platelet Count/methods* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sepsis/diagnosis* | - |
dc.subject.MESH | Sepsis/mortality* | - |
dc.title | Mean Platelet Volume to Platelet Count Ratio as a Promising Predictor of Early Mortality in Severe Sepsis | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Emergency Medicine | - |
dc.contributor.googleauthor | Geun Ho Oh | - |
dc.contributor.googleauthor | Sung Phil Chung | - |
dc.contributor.googleauthor | Yoo Seok Park | - |
dc.contributor.googleauthor | Jung Hwa Hong | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Hyun Soo Chung | - |
dc.contributor.googleauthor | Je Sung You | - |
dc.contributor.googleauthor | Jong Woo Park | - |
dc.contributor.googleauthor | Incheol Park | - |
dc.identifier.doi | 10.1097/SHK.0000000000000718 | - |
dc.contributor.localId | A03764 | - |
dc.contributor.localId | A04433 | - |
dc.contributor.localId | A05151 | - |
dc.contributor.localId | A01628 | - |
dc.contributor.localId | A02507 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A03625 | - |
dc.contributor.localId | A01592 | - |
dc.relation.journalcode | J02658 | - |
dc.identifier.eissn | 1540-0514 | - |
dc.identifier.pmid | 27504801 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201703000-00010&LSLINK=80&D=ovft | - |
dc.subject.keyword | Mean platelet volume | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | platelet | - |
dc.subject.keyword | predictor | - |
dc.subject.keyword | sepsis | - |
dc.subject.keyword | shock | - |
dc.contributor.alternativeName | Park, Yoo Seok | - |
dc.contributor.alternativeName | Chung, Hyun Soo | - |
dc.contributor.alternativeName | Hong, Jung Hwa | - |
dc.contributor.alternativeName | Oh, Geun Ho | - |
dc.contributor.alternativeName | Park, In Cheol | - |
dc.contributor.alternativeName | You, Je Sung | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Chung, Sung Pil | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Soo | - |
dc.contributor.affiliatedAuthor | Hong, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Oh, Geun Ho | - |
dc.contributor.affiliatedAuthor | Park, In Cheol | - |
dc.contributor.affiliatedAuthor | You, Je Sung | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Chung, Sung Pil | - |
dc.contributor.affiliatedAuthor | Park, Yoo Seok | - |
dc.citation.title | Shock | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 323 | - |
dc.citation.endPage | 330 | - |
dc.identifier.bibliographicCitation | SHOCK, Vol.47(3) : 323-330, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42912 | - |
dc.type.rims | ART | - |
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