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Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

 Hansol Lee  ;  Joonsung Lee  ;  Eunhae Joe  ;  Seungwook Yang  ;  Jae Eun Song  ;  Young-Suk Choi  ;  Eunkyung Wang  ;  Chan Gyu Joo  ;  Ho-Taek Song  ;  Dong-Hyun Kim 
 Magnetic Resonance in Medicine, Vol.78(5) : 1674-1682, 2017 
Journal Title
 Magnetic Resonance in Medicine 
Issue Date
Purpose : To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4?T. Methods : The trade-off between the amount of flow suppression using bipolar gradients and math formula effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non?flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor?bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results : The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P?<?0.05) in the tumor region after flow suppression. Conclusion : Optimization of the bipolar gradient is essential because of the short 13C math formula and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing math formula-related signal loss in stationary tissues at 9.4?T. Magn Reson Med, 2016. ? 2016 International Society for Magnetic Resonance in Medicine.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
송호택(Song, Ho Taek) ORCID logo https://orcid.org/0000-0002-6655-2575
주찬규(Joo, Chan Gyu) ORCID logo https://orcid.org/0000-0002-1415-9245
최영숙(Choi, Young Suk) ORCID logo https://orcid.org/0000-0003-4930-8455
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