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Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

DC FieldValueLanguage
dc.contributor.author송호택-
dc.contributor.author주찬규-
dc.contributor.author최영숙-
dc.date.accessioned2017-10-26T08:31:13Z-
dc.date.available2017-10-26T08:31:13Z-
dc.date.issued2017-
dc.identifier.issn0740-3194-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153254-
dc.description.abstractPurpose : To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4?T. Methods : The trade-off between the amount of flow suppression using bipolar gradients and math formula effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non?flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor?bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results : The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P?<?0.05) in the tumor region after flow suppression. Conclusion : Optimization of the bipolar gradient is essential because of the short 13C math formula and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing math formula-related signal loss in stationary tissues at 9.4?T. Magn Reson Med, 2016. ? 2016 International Society for Magnetic Resonance in Medicine.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfMagnetic Resonance in Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFlow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorHansol Lee-
dc.contributor.googleauthorJoonsung Lee-
dc.contributor.googleauthorEunhae Joe-
dc.contributor.googleauthorSeungwook Yang-
dc.contributor.googleauthorJae Eun Song-
dc.contributor.googleauthorYoung-Suk Choi-
dc.contributor.googleauthorEunkyung Wang-
dc.contributor.googleauthorChan Gyu Joo-
dc.contributor.googleauthorHo-Taek Song-
dc.contributor.googleauthorDong-Hyun Kim-
dc.identifier.doi10.1002/mrm.26578-
dc.contributor.localIdA05044-
dc.contributor.localIdA04693-
dc.contributor.localIdA02080-
dc.relation.journalcodeJ02179-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/mrm.26578/abstract-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameJoo, Chan Gyu-
dc.contributor.alternativeNameChoi, Young Suk-
dc.contributor.affiliatedAuthorJoo, Chan Gyu-
dc.contributor.affiliatedAuthorChoi, Young Suk-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.citation.volume78-
dc.citation.number5-
dc.citation.startPage1674-
dc.citation.endPage1682-
dc.identifier.bibliographicCitationMagnetic Resonance in Medicine, Vol.78(5) : 1674-1682, 2017-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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