0 605

Cited 25 times in

Incremental Prognostic Value of ADC Histogram Analysis over MGMT Promoter Methylation Status in Patients with Glioblastoma

 Yoon Seong Choi  ;  Sung Soo Ahn  ;  Dong Wook Kim  ;  Jong Hee Chang  ;  Seok-Gu Kang  ;  Eui Hyun Kim  ;  Se Hoon Kim  ;  Tyler Hyungtaek Rim  ;  Seung-Koo Lee 
 RADIOLOGY, Vol.281(1) : 175-184, 2016 
Journal Title
Issue Date
Brain Neoplasms/diagnostic imaging* ; Brain Neoplasms/genetics* ; Brain Neoplasms/therapy ; DNA Methylation* ; DNA Modification Methylases/genetics* ; DNA Repair Enzymes/genetics* ; Diffusion Magnetic Resonance Imaging/methods* ; Female ; Glioblastoma/diagnostic imaging* ; Glioblastoma/genetics* ; Glioblastoma/therapy ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Promoter Regions, Genetic ; Retrospective Studies ; Survival Rate ; Tumor Suppressor Proteins/genetics*
Purpose To investigate the incremental prognostic value of apparent diffusion coefficient (ADC) histogram analysis over oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status in patients with glioblastoma and the correlation between ADC parameters and MGMT status. Materials and Methods This retrospective study was approved by institutional review board, and informed consent was waived. A total of 112 patients with glioblastoma were divided into training (74 patients) and test (38 patients) sets. Overall survival (OS) and progression-free survival (PFS) was analyzed with ADC parameters, MGMT status, and other clinical factors. Multivariate Cox regression models with and without ADC parameters were constructed. Model performance was assessed with c index and receiver operating characteristic curve analyses for 12- and 16-month OS and 12-month PFS in the training set and validated in the test set. ADC parameters were compared according to MGMT status for the entire cohort. Results By using ADC parameters, the c indices and diagnostic accuracies for 12- and 16-month OS and 12-month PFS in the models showed significant improvement, with the exception of c indices in the models for PFS (P < .05 for all) in the training set. In the test set, the diagnostic accuracy was improved by using ADC parameters and was significant, with the 25th and 50th percentiles of ADC for 16-month OS (P = .040 and P = .047) and the 25th percentile of ADC for 12-month PFS (P = .026). No significant correlation was found between ADC parameters and MGMT status. Conclusion ADC histogram analysis had incremental prognostic value over MGMT promoter methylation status in patients with glioblastoma. (?) RSNA, 2016 Online supplemental material is available for this article.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Eui Hyun(김의현) ORCID logo https://orcid.org/0000-0002-2523-7122
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Rim, Tyler Hyungtaek(임형택)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Choi, Yoon Seong(최윤성)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.