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Incremental Prognostic Value of ADC Histogram Analysis over MGMT Promoter Methylation Status in Patients with Glioblastoma

DC FieldValueLanguage
dc.contributor.author강석구-
dc.contributor.author김세훈-
dc.contributor.author김의현-
dc.contributor.author안성수-
dc.contributor.author이승구-
dc.contributor.author임형택-
dc.contributor.author장종희-
dc.contributor.author최윤성-
dc.date.accessioned2017-10-26T07:31:21Z-
dc.date.available2017-10-26T07:31:21Z-
dc.date.issued2016-
dc.identifier.issn0033-8419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152139-
dc.description.abstractPurpose To investigate the incremental prognostic value of apparent diffusion coefficient (ADC) histogram analysis over oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status in patients with glioblastoma and the correlation between ADC parameters and MGMT status. Materials and Methods This retrospective study was approved by institutional review board, and informed consent was waived. A total of 112 patients with glioblastoma were divided into training (74 patients) and test (38 patients) sets. Overall survival (OS) and progression-free survival (PFS) was analyzed with ADC parameters, MGMT status, and other clinical factors. Multivariate Cox regression models with and without ADC parameters were constructed. Model performance was assessed with c index and receiver operating characteristic curve analyses for 12- and 16-month OS and 12-month PFS in the training set and validated in the test set. ADC parameters were compared according to MGMT status for the entire cohort. Results By using ADC parameters, the c indices and diagnostic accuracies for 12- and 16-month OS and 12-month PFS in the models showed significant improvement, with the exception of c indices in the models for PFS (P < .05 for all) in the training set. In the test set, the diagnostic accuracy was improved by using ADC parameters and was significant, with the 25th and 50th percentiles of ADC for 16-month OS (P = .040 and P = .047) and the 25th percentile of ADC for 12-month PFS (P = .026). No significant correlation was found between ADC parameters and MGMT status. Conclusion ADC histogram analysis had incremental prognostic value over MGMT promoter methylation status in patients with glioblastoma. (?) RSNA, 2016 Online supplemental material is available for this article.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRadiological Society of North America-
dc.relation.isPartOfRadiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBrain Neoplasms/diagnostic imaging*-
dc.subject.MESHBrain Neoplasms/genetics*-
dc.subject.MESHBrain Neoplasms/therapy-
dc.subject.MESHDNA Methylation*-
dc.subject.MESHDNA Modification Methylases/genetics*-
dc.subject.MESHDNA Repair Enzymes/genetics*-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHFemale-
dc.subject.MESHGlioblastoma/diagnostic imaging*-
dc.subject.MESHGlioblastoma/genetics*-
dc.subject.MESHGlioblastoma/therapy-
dc.subject.MESHHumans-
dc.subject.MESHImage Interpretation, Computer-Assisted-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTumor Suppressor Proteins/genetics*-
dc.titleIncremental Prognostic Value of ADC Histogram Analysis over MGMT Promoter Methylation Status in Patients with Glioblastoma-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorYoon Seong Choi-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorEui Hyun Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorTyler Hyungtaek Rim-
dc.contributor.googleauthorSeung-Koo Lee-
dc.identifier.doi10.1148/radiol.2016151913-
dc.contributor.localIdA00610-
dc.contributor.localIdA00837-
dc.contributor.localIdA02234-
dc.contributor.localIdA02912-
dc.contributor.localIdA03419-
dc.contributor.localIdA03470-
dc.contributor.localIdA04137-
dc.contributor.localIdA00036-
dc.relation.journalcodeJ02596-
dc.identifier.pmid27120357-
dc.identifier.urlhttp://pubs.rsna.org/doi/10.1148/radiol.2016151913-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Eui Hyun-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameRim, Tyler H. T.-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameChoi, Yoon Seong-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Eui Hyun-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorRim, Tyler Hyungtaek-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorChoi, Yoon Seong-
dc.contributor.affiliatedAuthorKang, Seok Gu-
dc.citation.volume281-
dc.citation.number1-
dc.citation.startPage175-
dc.citation.endPage184-
dc.identifier.bibliographicCitationRadiology, Vol.281(1) : 175-184, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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