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Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

Authors
 Chan Kim  ;  Eun Kyung Kim  ;  Hun Jung  ;  Hong Jae Chon  ;  Jung Woo Han  ;  Kyoo-Ho Shin  ;  Hyuk Hu  ;  Kyung Sik Kim  ;  Young Deuk Choi  ;  Sunghoon Kim  ;  Young Han Lee  ;  Jin-Suck Suh  ;  Joong Bae Ahn  ;  Hyun Cheol Chung  ;  Sung Hoon Noh  ;  Sun Young Rha  ;  Soo Hee Kim  ;  Hyo Song Kim 
Citation
 BMC CANCER, Vol.16 : 434, 2016 
Journal Title
 BMC CANCER 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; B7-H1 Antigen/metabolism* ; Biomarkers, Tumor/metabolism* ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Sarcoma/metabolism* ; Sarcoma/mortality ; Sarcoma/pathology ; Soft Tissue Neoplasms/metabolism* ; Soft Tissue Neoplasms/mortality ; Soft Tissue Neoplasms/pathology ; Young Adult
Keywords
Biomarker ; PD-L1 ; Prognosis ; Soft tissue sarcoma
Abstract
BACKGROUND: The PD-1/PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its clinical implication in soft-tissue sarcomas (STS). METHODS: We analyzed PD-L1 expression in 82 STS patients with 5 subtypes: rhabdomyosarcoma, synovial sarcoma, Ewing sarcoma, epithelioid sarcoma, and mesenchymal chondrosarcoma. RESULTS: The median age at diagnosis was 26 (range: 1-78) and the male to female ratio was 1.6. The majority (80 %) of patients showed locoregional disease rather than metastatic disease at diagnosis. Thirty-five cases (43 %) showed PD-L1 expression and the proportion of PD-L1 expression was significantly different according to histologic subtypes (P?=?0.004); highest in epithelioid sarcoma (100 %, 7/7), followed by synovial sarcoma (53 %, 10/19), rhabdomyosarcoma (38 %, 12/32), and Ewing sarcoma (33 %, 6/18), while it was not expressed in mesenchymal chondrosarcoma (0 %, 0/6). STS patients with PD-L1 expression had worse overall survival compared with those without PD-L1 expression (5-year survival rate: 48 % vs. 68 %, P?=?0.015). The Cox proportional hazard model adjusted for histologic subtype, initial metastasis, and PD-L1 expression showed that PD-L1 expression was significantly associated with shorter overall survival (P?=?0.037, HR 2.57, 95 % CI 1.060-6.231). CONCLUSION: We have confirmed PD-L1 expression in various STS of young population and demonstrated its independent negative prognostic role, thereby suggesting the PD-1/PD-L1 axis as a potential therapeutic target for the treatment of young STS patients.
DOI
10.1186/s12885-016-2451-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Shin, Kyoo Ho(신규호)
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151623
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