Cited 126 times in
Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma
DC Field | Value | Language |
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dc.contributor.author | 김효송 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 신규호 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 이영한 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 허혁 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김경식 | - |
dc.date.accessioned | 2017-10-26T07:07:08Z | - |
dc.date.available | 2017-10-26T07:07:08Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151623 | - |
dc.description.abstract | BACKGROUND: The PD-1/PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its clinical implication in soft-tissue sarcomas (STS). METHODS: We analyzed PD-L1 expression in 82 STS patients with 5 subtypes: rhabdomyosarcoma, synovial sarcoma, Ewing sarcoma, epithelioid sarcoma, and mesenchymal chondrosarcoma. RESULTS: The median age at diagnosis was 26 (range: 1-78) and the male to female ratio was 1.6. The majority (80 %) of patients showed locoregional disease rather than metastatic disease at diagnosis. Thirty-five cases (43 %) showed PD-L1 expression and the proportion of PD-L1 expression was significantly different according to histologic subtypes (P?=?0.004); highest in epithelioid sarcoma (100 %, 7/7), followed by synovial sarcoma (53 %, 10/19), rhabdomyosarcoma (38 %, 12/32), and Ewing sarcoma (33 %, 6/18), while it was not expressed in mesenchymal chondrosarcoma (0 %, 0/6). STS patients with PD-L1 expression had worse overall survival compared with those without PD-L1 expression (5-year survival rate: 48 % vs. 68 %, P?=?0.015). The Cox proportional hazard model adjusted for histologic subtype, initial metastasis, and PD-L1 expression showed that PD-L1 expression was significantly associated with shorter overall survival (P?=?0.037, HR 2.57, 95 % CI 1.060-6.231). CONCLUSION: We have confirmed PD-L1 expression in various STS of young population and demonstrated its independent negative prognostic role, thereby suggesting the PD-1/PD-L1 axis as a potential therapeutic target for the treatment of young STS patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | B7-H1 Antigen/metabolism* | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sarcoma/metabolism* | - |
dc.subject.MESH | Sarcoma/mortality | - |
dc.subject.MESH | Sarcoma/pathology | - |
dc.subject.MESH | Soft Tissue Neoplasms/metabolism* | - |
dc.subject.MESH | Soft Tissue Neoplasms/mortality | - |
dc.subject.MESH | Soft Tissue Neoplasms/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Chan Kim | - |
dc.contributor.googleauthor | Eun Kyung Kim | - |
dc.contributor.googleauthor | Hun Jung | - |
dc.contributor.googleauthor | Hong Jae Chon | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Kyoo-Ho Shin | - |
dc.contributor.googleauthor | Hyuk Hu | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Young Han Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Soo Hee Kim | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.identifier.doi | 10.1186/s12885-016-2451-6 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02086 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A02967 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A04373 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00299 | - |
dc.relation.journalcode | J00351 | - |
dc.identifier.eissn | 1471-2407 | - |
dc.relation.journalsince | 2001~ | - |
dc.identifier.pmid | 27393385 | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | PD-L1 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Soft tissue sarcoma | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Shin, Kyoo Ho | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Lee, Young Han | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.alternativeName | Hur, Hyuk | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Shin, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Lee, Young Han | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Hur, Hyuk | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 434 | - |
dc.identifier.bibliographicCitation | BMC CANCER, Vol.16 : 434, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45259 | - |
dc.type.rims | ART | - |
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