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Prognostic implications of PIK3CA amplification in curatively resected liposarcoma

 Joo Hoon Kim  ;  Jae Seok Lee  ;  Eo Jin Kim  ;  Kyu Hyun Park  ;  Ki Hyang Kim  ;  Seong Yoon Yi  ;  Han Seong Kim  ;  Yong Jin Cho  ;  Kyoo-Ho Shin  ;  Joong Bae Ahn  ;  Hyuk Hu  ;  Kyung Sik Kim  ;  Young Deuk Choi  ;  Sunghoon Kim  ;  Young Han Lee  ;  Jin-Suck Suh  ;  Sung Hoon Noh  ;  Sun Young Rha  ;  Hyo Song Kim 
 Oncotarget, Vol.7(17) : 24549-24558, 2016 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Class I Phosphatidylinositol 3-Kinases/genetics* ; DNA Copy Number Variations ; Female ; Gene Amplification* ; Humans ; In Situ Hybridization, Fluorescence ; Kaplan-Meier Estimate ; Liposarcoma/diagnosis ; Liposarcoma/genetics* ; Liposarcoma/surgery ; Male ; Middle Aged ; Mutation* ; Prognosis ; Young Adult
PIK3CA ; amplification ; liposarcoma ; mutation
BACKGROUND: We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma. PATIENTS AND METHODS: A total of 125 liposarcoma tissue samples were collected over a 12-year period. PIK3CA mutations and gene copy number amplifications were analyzed by pyrosequencing and fluorescence in situ hybridization (FISH). RESULTS: Nine of the 105 liposarcomas (8.6%) had activating PIK3CA mutation. PIK3CA mutations were more frequent in myxoid/round cell and pleomorphic tumors compared with well-differentiated/dedifferentiated tumors (13.3% vs. 2.2%, P=0.043). In FISH PIK3CA analysis, copy number gain was detected in 14 of the 101 tumors (13.9%): 11 (10.9%) tumors had increased gene copy number (polysomy) and 3 (3.0%) exhibited gene amplification. In survival analysis, patients with PIK3CA copy number gain had a worse prognosis compared to patients without PIK3CA amplification (median disease-free survival [DFS] 22.2 vs. 107.6 months p=0.005). By multivariate analysis, PIK3CA copy number gain was an independent prognostic factor for worse DFS (P=0.027; hazard ratio, 2.400; 95% confidence interval 1.105 to 5.213). PIK3CA mutation was not associated with DFS and overall survival. CONCLUSIONS: We demonstrated PIK3CA mutation and amplification in liposarcoma. PIK3CA copy number gain was an independent poor prognostic factor for DFS. Further studies are needed to evaluate the potential diagnostic and therapeutic role of PIK3CA mutations and amplifications in liposarcoma.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Joo Hoon(김주훈)
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Park, Kyu Hyun(박규현)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Shin, Kyoo Ho(신규호)
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
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