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Prognostic implications of PIK3CA amplification in curatively resected liposarcoma

DC Field Value Language
dc.contributor.author김경식-
dc.contributor.author김성훈-
dc.contributor.author라선영-
dc.contributor.author박규현-
dc.contributor.author서진석-
dc.contributor.author신규호-
dc.contributor.author안중배-
dc.contributor.author이영한-
dc.contributor.author최영득-
dc.contributor.author허혁-
dc.contributor.author김효송-
dc.contributor.author노성훈-
dc.contributor.author김주훈-
dc.date.accessioned2017-02-27T08:26:26Z-
dc.date.available2017-02-27T08:26:26Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147186-
dc.description.abstractBACKGROUND: We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma. PATIENTS AND METHODS: A total of 125 liposarcoma tissue samples were collected over a 12-year period. PIK3CA mutations and gene copy number amplifications were analyzed by pyrosequencing and fluorescence in situ hybridization (FISH). RESULTS: Nine of the 105 liposarcomas (8.6%) had activating PIK3CA mutation. PIK3CA mutations were more frequent in myxoid/round cell and pleomorphic tumors compared with well-differentiated/dedifferentiated tumors (13.3% vs. 2.2%, P=0.043). In FISH PIK3CA analysis, copy number gain was detected in 14 of the 101 tumors (13.9%): 11 (10.9%) tumors had increased gene copy number (polysomy) and 3 (3.0%) exhibited gene amplification. In survival analysis, patients with PIK3CA copy number gain had a worse prognosis compared to patients without PIK3CA amplification (median disease-free survival [DFS] 22.2 vs. 107.6 months p=0.005). By multivariate analysis, PIK3CA copy number gain was an independent prognostic factor for worse DFS (P=0.027; hazard ratio, 2.400; 95% confidence interval 1.105 to 5.213). PIK3CA mutation was not associated with DFS and overall survival. CONCLUSIONS: We demonstrated PIK3CA mutation and amplification in liposarcoma. PIK3CA copy number gain was an independent poor prognostic factor for DFS. Further studies are needed to evaluate the potential diagnostic and therapeutic role of PIK3CA mutations and amplifications in liposarcoma.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHClass I Phosphatidylinositol 3-Kinases/genetics*-
dc.subject.MESHDNA Copy Number Variations-
dc.subject.MESHFemale-
dc.subject.MESHGene Amplification*-
dc.subject.MESHHumans-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiposarcoma/diagnosis-
dc.subject.MESHLiposarcoma/genetics*-
dc.subject.MESHLiposarcoma/surgery-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHPrognosis-
dc.subject.MESHYoung Adult-
dc.titlePrognostic implications of PIK3CA amplification in curatively resected liposarcoma-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJoo Hoon Kim-
dc.contributor.googleauthorJae Seok Lee-
dc.contributor.googleauthorEo Jin Kim-
dc.contributor.googleauthorKyu Hyun Park-
dc.contributor.googleauthorKi Hyang Kim-
dc.contributor.googleauthorSeong Yoon Yi-
dc.contributor.googleauthorHan Seong Kim-
dc.contributor.googleauthorYong Jin Cho-
dc.contributor.googleauthorKyoo-Ho Shin-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorHyuk Hu-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYoung Han Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyo Song Kim-
dc.identifier.doi10.18632/oncotarget.8240-
dc.contributor.localIdA00299-
dc.contributor.localIdA00595-
dc.contributor.localIdA01316-
dc.contributor.localIdA04566-
dc.contributor.localIdA01916-
dc.contributor.localIdA02086-
dc.contributor.localIdA02262-
dc.contributor.localIdA02967-
dc.contributor.localIdA04111-
dc.contributor.localIdA04373-
dc.contributor.localIdA01202-
dc.contributor.localIdA01281-
dc.contributor.localIdA00949-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid27016421-
dc.subject.keywordPIK3CA-
dc.subject.keywordamplification-
dc.subject.keywordliposarcoma-
dc.subject.keywordmutation-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Kyu Hyun-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLee, Young Han-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameKim, Joo Hoon-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorPark, Kyu Hyun-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLee, Young Han-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Joo Hoon-
dc.citation.volume7-
dc.citation.number17-
dc.citation.startPage24549-
dc.citation.endPage24558-
dc.identifier.bibliographicCitationONCOTARGET , Vol.7(17) : 24549-24558, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47603-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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