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HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation

 SJ Han  ;  HJ Min  ;  SC Yoon  ;  EA Ko  ;  SJ Park  ;  J-H Yoon  ;  J-S Shin  ;  KY Seo 
 Cell Death & Disease, Vol.6 : 1863-1863, 2015 
Journal Title
 Cell Death & Disease 
Issue Date
High-mobility group box 1 (HMGB1) functions as a transcription-enhancing nuclear protein as well as a crucial cytokine that regulates inflammation. This study demonstrated that secretion of HMGB1 due to ultraviolet (UV) radiation inducing ocular surface inflammation-mediated reactive oxygen species (ROS) production. After treating conjunctival epithelial cells with UV radiation, HMGB1 was translocated from the nucleus to the cytoplasm and then eventually to the extracellular space. HMGB1 played a crucial role in UV-induced conjunctival neutrophil infiltration, which subsided when mice were pretreated with the HMGB1 inhibitors soluble receptor for advanced glycation endproducts (sRAGEs) and HMGB1 A box protein. In case of using ROS quencher, there was decrease in UV-induced HMGB1 secretion in conjunctival epithelial cells and mice. Considering that UV-induced chronic inflammation causes ocular surface change as pterygium, we have confirmed high HMGB1 translocation and ROS expression in human pterygium. Our findings therefore revealed a previously unknown mechanism of UV-induced ocular inflammation related to ROS and HMGB1 suggesting a new medical therapeutic target.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
서경률(Seo, Kyuong Yul) ORCID logo https://orcid.org/0000-0002-9855-1980
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
윤상철(Yoon, Sang Chul) ORCID logo https://orcid.org/0000-0003-0454-9597
윤주헌(Yoon, Joo Heon)
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