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Cited 21 times in

HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation

DC Field Value Language
dc.contributor.author서경률-
dc.contributor.author신전수-
dc.contributor.author윤상철-
dc.contributor.author윤주헌-
dc.date.accessioned2016-02-04T11:41:17Z-
dc.date.available2016-02-04T11:41:17Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140976-
dc.description.abstractHigh-mobility group box 1 (HMGB1) functions as a transcription-enhancing nuclear protein as well as a crucial cytokine that regulates inflammation. This study demonstrated that secretion of HMGB1 due to ultraviolet (UV) radiation inducing ocular surface inflammation-mediated reactive oxygen species (ROS) production. After treating conjunctival epithelial cells with UV radiation, HMGB1 was translocated from the nucleus to the cytoplasm and then eventually to the extracellular space. HMGB1 played a crucial role in UV-induced conjunctival neutrophil infiltration, which subsided when mice were pretreated with the HMGB1 inhibitors soluble receptor for advanced glycation endproducts (sRAGEs) and HMGB1 A box protein. In case of using ROS quencher, there was decrease in UV-induced HMGB1 secretion in conjunctival epithelial cells and mice. Considering that UV-induced chronic inflammation causes ocular surface change as pterygium, we have confirmed high HMGB1 translocation and ROS expression in human pterygium. Our findings therefore revealed a previously unknown mechanism of UV-induced ocular inflammation related to ROS and HMGB1 suggesting a new medical therapeutic target.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfCELL DEATH & DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHCell Nucleus/metabolism-
dc.subject.MESHCell Nucleus/radiation effects-
dc.subject.MESHConjunctiva/metabolism-
dc.subject.MESHConjunctiva/pathology-
dc.subject.MESHConjunctiva/radiation effects*-
dc.subject.MESHCytoplasm/metabolism-
dc.subject.MESHCytoplasm/radiation effects-
dc.subject.MESHEpithelial Cells/metabolism-
dc.subject.MESHEpithelial Cells/pathology-
dc.subject.MESHEpithelial Cells/radiation effects*-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHHMGB1 Protein/genetics-
dc.subject.MESHHMGB1 Protein/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHProtein Transport-
dc.subject.MESHPterygium/etiology-
dc.subject.MESHPterygium/genetics-
dc.subject.MESHPterygium/metabolism*-
dc.subject.MESHPterygium/pathology-
dc.subject.MESHReactive Oxygen Species/agonists-
dc.subject.MESHReactive Oxygen Species/metabolism*-
dc.subject.MESHReceptor for Advanced Glycation End Products/chemistry-
dc.subject.MESHReceptor for Advanced Glycation End Products/genetics-
dc.subject.MESHReceptor for Advanced Glycation End Products/metabolism-
dc.subject.MESHSignal Transduction-
dc.subject.MESHUltraviolet Rays/adverse effects*-
dc.titleHMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorSJ Han-
dc.contributor.googleauthorHJ Min-
dc.contributor.googleauthorSC Yoon-
dc.contributor.googleauthorEA Ko-
dc.contributor.googleauthorSJ Park-
dc.contributor.googleauthorJ-H Yoon-
dc.contributor.googleauthorJ-S Shin-
dc.contributor.googleauthorKY Seo-
dc.identifier.doi10.1038/cddis.2015.199-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01870-
dc.contributor.localIdA02144-
dc.contributor.localIdA02560-
dc.contributor.localIdA02604-
dc.relation.journalcodeJ00482-
dc.identifier.eissn2041-4889-
dc.identifier.pmid26313914-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameShin, Jeon Soo-
dc.contributor.alternativeNameYoon, Sang Chul-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorShin, Jeon Soo-
dc.contributor.affiliatedAuthorYoon, Sang Chul-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.rights.accessRightsfree-
dc.citation.volume6-
dc.citation.startPage1863-
dc.identifier.bibliographicCitationCELL DEATH & DISEASE, Vol.6 : 1863, 2015-
dc.identifier.rimsid30431-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Humanities and Social Sciences (인문사회의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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