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Possible Contrast Media Reduction with Low keV Monoenergetic Images in the Detection of Focal Liver Lesions: A Dual-Energy CT Animal Study

Authors
 Yong Eun Chung  ;  Je Sung You  ;  Hye-Jeong Lee  ;  Joon Seok Lim  ;  Hye Sun Lee  ;  Song Ee Baek  ;  Myeong-Jin Kim 
Citation
 PLoS One, Vol.10(7) : e0133170, 2015 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2015
Abstract
OBJECTIVE: To investigate the feasibility of dual-energy CT for contrast media (CM) reduction in the diagnosis of hypervascular and hypovascular focal liver lesions (FLL). SUBJECTS AND METHODS: The Institutional Animal Care and Use Committee approved this study. VX2 tumors were implanted in two different segments of the liver in 13 rabbits. After 2 weeks, two phase contrast enhanced CT scans including the arterial phase (AP) and portal-venous phase (PVP) were performed three times with 24-hour intervals with three different concentrations of iodine, 300 (I(300)), 150 (I(150)) and 75 mg I/mL (I(75)). The mean HU and standard deviation (SD) were measured in the liver, the hypervascular portion of the VX2 tumor which represented hypervascular tumors, and the central necrotic area of the VX2 tumor which represented hypovascular tumors in 140 kVp images with I(300) as a reference standard and in monoenergetic images (between 40 keV and 140 keV) with I(150) and I(75). The contrast-to-noise ratio (CNR) for FLLs and the ratio of the CNRs (CNR(ratio)) between monoenergetic image sets with I(150) and I(75), and the reference standard were calculated. RESULTS: For hypervascular lesions, the CNR(ratio) was not statistically different from 1.0 between 40 keV and 70 keV images with I(150), whereas the CNR(ratio) was significantly lower than 1.0 in all keV images with I(75). For hypovascular lesions, the CNR(ratio) was similar to or higher than 1.0 between 40 keV and 80 keV with I(150) and between 40 keV and 70 keV with I(75).. CONCLUSIONS: With dual-energy CT, the total amount of CM might be halved in the diagnosis of hypervascular FLLs and reduced to one-fourth in the diagnosis of hypovascular FLLs, while still preserving CNRs.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140739
DOI
10.1371/journal.pone.0133170
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김명진(Kim, Myeong Jin) ; 백송이(Baek, Song Ee) ; 유제성(You, Je Sung) ; 이혜선(Lee, Hye Sun) ; 이혜정(Lee, Hye Jeong) ; 임준석(Lim, Joon Seok) ; 정용은(Chung, Yong Eun)
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