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Possible Contrast Media Reduction with Low keV Monoenergetic Images in the Detection of Focal Liver Lesions: A Dual-Energy CT Animal Study

 Yong Eun Chung  ;  Je Sung You  ;  Hye-Jeong Lee  ;  Joon Seok Lim  ;  Hye Sun Lee  ;  Song Ee Baek  ;  Myeong-Jin Kim 
 PLOS ONE, Vol.10(7) : e0133170, 2015 
Journal Title
Issue Date
Animals ; Aortography ; Contrast Media*/administration & dosage ; Dose-Response Relationship, Drug ; Feasibility Studies ; Iohexol*/administration & dosage ; Liver Neoplasms, Experimental/blood supply ; Liver Neoplasms, Experimental/diagnostic imaging* ; Multidetector Computed Tomography/methods* ; Neoplasm Transplantation ; Neovascularization, Pathologic/diagnostic imaging ; Rabbits ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed/methods*
OBJECTIVE: To investigate the feasibility of dual-energy CT for contrast media (CM) reduction in the diagnosis of hypervascular and hypovascular focal liver lesions (FLL). SUBJECTS AND METHODS: The Institutional Animal Care and Use Committee approved this study. VX2 tumors were implanted in two different segments of the liver in 13 rabbits. After 2 weeks, two phase contrast enhanced CT scans including the arterial phase (AP) and portal-venous phase (PVP) were performed three times with 24-hour intervals with three different concentrations of iodine, 300 (I(300)), 150 (I(150)) and 75 mg I/mL (I(75)). The mean HU and standard deviation (SD) were measured in the liver, the hypervascular portion of the VX2 tumor which represented hypervascular tumors, and the central necrotic area of the VX2 tumor which represented hypovascular tumors in 140 kVp images with I(300) as a reference standard and in monoenergetic images (between 40 keV and 140 keV) with I(150) and I(75). The contrast-to-noise ratio (CNR) for FLLs and the ratio of the CNRs (CNR(ratio)) between monoenergetic image sets with I(150) and I(75), and the reference standard were calculated. RESULTS: For hypervascular lesions, the CNR(ratio) was not statistically different from 1.0 between 40 keV and 70 keV images with I(150), whereas the CNR(ratio) was significantly lower than 1.0 in all keV images with I(75). For hypovascular lesions, the CNR(ratio) was similar to or higher than 1.0 between 40 keV and 80 keV with I(150) and between 40 keV and 70 keV with I(75).. CONCLUSIONS: With dual-energy CT, the total amount of CM might be halved in the diagnosis of hypervascular FLLs and reduced to one-fourth in the diagnosis of hypovascular FLLs, while still preserving CNRs.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Baek, Song Ee(백송이) ORCID logo https://orcid.org/0000-0001-8146-2570
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
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