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Microscopic analysis of molar--incisor malformation.

 Hyo-Seol Lee  ;  Soo-Hyun Kim  ;  Seong-Oh Kim  ;  Byung-Jai Choi  ;  Sung-Won Cho  ;  Wonse Park  ;  Je Seon Song 
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.119(5) : 544-552, 2015 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology 
Issue Date
OBJECTIVE: Molar-incisor malformation (MIM) is a newly discovered type of dental anomaly that involves a characteristic root malformation of the permanent first molars. The aim of this study was to reveal the microstructure of MIM teeth in order to determine their origin. STUDY DESIGN: Four MIM teeth were extracted from a 9-year-old girl due to severe mobility. The detailed microstructure of the teeth was determined by examinations with micro-computed tomography (micro-CT), hematoxylin and eosin (H&E) staining, immunohistochemical staining, and scanning electron microscopy to reveal the detailed microstructure. RESULTS: Micro-CT and H&E staining revealed the pulpal floor comprising three layers: upper, middle, and lower. Amorphous hard tissues and hyperactive cells were observed in the middle layer of the pulpal floor, and the cells stained positively for dentin sialoprotein and osteocalcin, but not for collagen XII. CONCLUSION: The results of the present study imply that MIM-affected molars probably result from inappropriate differentiation of the apical pulp and dental follicle.
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2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Oh(김성오) ORCID logo https://orcid.org/0000-0002-8620-1377
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Lee, Hyo Seol(이효설)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
Choi, Byung Jai(최병재)
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