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T 2 - and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent

 Young Han Lee  ;  Dan Heo  ;  Myeonghwan Hwang  ;  Bongjune Kim  ;  Soeckgu Kang  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Jaemoon Yang  ;  Yong-Min Huh 
 RSC ADVANCES, Vol.5(25) : 19708-19714, 2015 
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In this study, T2- and T*2-weighted imaging potential of polysorbate-coated magnetic nanocrystals (P-MNCs) was investigated as a blood-pool contrast agent using a 9L-rat glioma model after intravenous injection via 3.0T MRI. Magnetic nanocrystals (MNCs, Fe3O4) synthesized by the thermal decomposition method were coated with polysorbate 80 using a nanoemulsion method to generate a water-stable MRI contrast agent. The physical properties and MR imaging capability of P-MNCs were verified. The orthotopic tumor models were established by implanting 9L-rat glioma cells into the rat brain. After tail-vein injection of P-MNCs, T2- and T*2-weighted imaging of tumor sites was performed. Blood clearance and biodistribution studies were also performed. The hydrodynamic diameter of P-MNCs was 10.5 ± 0.8 nm and a spherical magnetic core was confirmed. The r2 value of P-MNCs was calculated to be 114.1 mM−1 s−1. Heterogeneous contrast T2-weighted MRI images of the 9L-rat glioma model were visualized at the tumor site before injecting the MRI contrast agent. In particular, T*2-weighted images demonstrated more obvious signal intensity changes than did T2-weighted images. Neovasculature in the tumor tissue was clearly observed in T*2 images compared with T2-weighted images. The blood half-life of P-MNCs was 2 h and the Fe ion concentration of blood had returned to the baseline after 16 h. Well-tailored P-MNCs can be effectively used as a novel MRI contrast agent for visualizing of vasculatures for solid tumors via T2- and T*2-weighted imaging.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Heo, Dan(허단)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
Hwang, Myeong Hwan(황명환)
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