Cited 3 times in
T 2 - and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 이영한 | - |
dc.contributor.author | 허단 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 황명환 | - |
dc.date.accessioned | 2016-02-04T11:06:09Z | - |
dc.date.available | 2016-02-04T11:06:09Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139667 | - |
dc.description.abstract | In this study, T2- and T*2-weighted imaging potential of polysorbate-coated magnetic nanocrystals (P-MNCs) was investigated as a blood-pool contrast agent using a 9L-rat glioma model after intravenous injection via 3.0T MRI. Magnetic nanocrystals (MNCs, Fe3O4) synthesized by the thermal decomposition method were coated with polysorbate 80 using a nanoemulsion method to generate a water-stable MRI contrast agent. The physical properties and MR imaging capability of P-MNCs were verified. The orthotopic tumor models were established by implanting 9L-rat glioma cells into the rat brain. After tail-vein injection of P-MNCs, T2- and T*2-weighted imaging of tumor sites was performed. Blood clearance and biodistribution studies were also performed. The hydrodynamic diameter of P-MNCs was 10.5 ± 0.8 nm and a spherical magnetic core was confirmed. The r2 value of P-MNCs was calculated to be 114.1 mM−1 s−1. Heterogeneous contrast T2-weighted MRI images of the 9L-rat glioma model were visualized at the tumor site before injecting the MRI contrast agent. In particular, T*2-weighted images demonstrated more obvious signal intensity changes than did T2-weighted images. Neovasculature in the tumor tissue was clearly observed in T*2 images compared with T2-weighted images. The blood half-life of P-MNCs was 2 h and the Fe ion concentration of blood had returned to the baseline after 16 h. Well-tailored P-MNCs can be effectively used as a novel MRI contrast agent for visualizing of vasculatures for solid tumors via T2- and T*2-weighted imaging. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 19708~19714 | - |
dc.relation.isPartOf | RSC ADVANCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | T 2 - and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Young Han Lee | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Myeonghwan Hwang | - |
dc.contributor.googleauthor | Bongjune Kim | - |
dc.contributor.googleauthor | Soeckgu Kang | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.identifier.doi | 10.1039/C4RA09846C | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00036 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02967 | - |
dc.contributor.localId | A04346 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04458 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J02626 | - |
dc.identifier.eissn | 2046-2069 | - |
dc.identifier.url | http://pubs.rsc.org/en/content/articlelanding/ra/2015/c4ra09846c#!divAbstract | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Lee, Young Han | - |
dc.contributor.alternativeName | Heo, Dan | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.alternativeName | Hwang, Myeong Hwan | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lee, Young Han | - |
dc.contributor.affiliatedAuthor | Heo, Dan | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Hwang, Myeong Hwan | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 5 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 19708 | - |
dc.citation.endPage | 19714 | - |
dc.identifier.bibliographicCitation | RSC ADVANCES, Vol.5(25) : 19708-19714, 2015 | - |
dc.identifier.rimsid | 52393 | - |
dc.type.rims | ART | - |
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