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Adjunctive biomarkers for improving diagnosis of tuberculosis and monitoring therapeutic effects.

 Yun Gyoung Hur  ;  Young Ae Kang  ;  Sun Hee Jang  ;  Ji Young Hong  ;  Ahreum Kim  ;  Sang A Lee  ;  Youngmi Kim  ;  Sang Nae Cho 
 JOURNAL OF INFECTION, Vol.70(4) : 346-355, 2015 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents/therapeutic use ; Biomarkers/blood* ; Chemokine CXCL10/blood ; Cytokines/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunologic Tests ; Interferon-gamma/blood ; Interleukin-2 ; Latent Tuberculosis/diagnosis* ; Latent Tuberculosis/drug therapy* ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/diagnosis* ; Reagent Kits, Diagnostic ; Tuberculin Test ; Tuberculosis/diagnosis* ; Tuberculosis/therapy* ; Tumor Necrosis Factor-alpha/blood ; Vascular Endothelial Growth Factor A/blood* ; Young Adult
Biomarker ; Diagnosis ; Latent tuberculosis infection (LTBI) ; Mycobacterium tuberculosis (M. tb) ; Nontuberculous mycobacteria (NTM) ; Treatment ; Tuberculosis (TB)
OBJECTIVES: To identify host biomarkers associated with latent tuberculosis infection (LTBI), active tuberculosis (TB), and nontuberculous mycobacteria (NTM) diseases to improve diagnosis and effective anti-TB treatment. METHODS: Active TB and NTM patients at diagnosis, recent TB contacts, and normal healthy subjects were recruited. Tuberculin skin tests, QuantiFERON-TB Gold In-Tube tests, and multiplex bead arrays with 17 analytes were performed. TB patients were re-evaluated after 2 and 6 months of treatment. RESULTS: Mycobacterium tuberculosis (M. tb) antigen-specific IFN-γ, IL-2, and CXCL10 responses were significantly higher in active TB and LTBI compared with controls (P < 0.01). Only serum VEGF levels varied between the active TB and LTBI groups (AUC = 0.7576, P < 0.001). Active TB and NTM diseases were differentiated by serum IL-2, IL-9, IL-13, IL-17, TNF-α and sCD40L levels (P < 0.05). Increased sCD40L and decreased M. tb antigen-specific IFN-γ levels correlated with sputum clearance of M. tb after 2 months of treatment (P < 0.001). CONCLUSIONS: Serum IL-2, IL-9, IL-13, IL-17, TNF-α, sCD40L and VEGF-A levels may be adjunctive biomarkers for differential diagnosis of active TB, LTBI, and NTM disease. Assessment of serum sCD40L and M. tb antigen-specific IFN-γ, TNF-α, and IL-2 levels could help predict successful anti-TB treatment in conjunction with M. tb clearance.
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Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Ah Reum(김아름) ORCID logo https://orcid.org/0000-0001-5938-4270
Kim, Young Mi(김영미)
Lee, Sang A(이상아)
Jang, Sun Hee(장선희)
Cho, Sang Nae(조상래)
Hur, Yun-Gyoung(허윤경) ORCID logo https://orcid.org/0000-0003-3986-4394
Hong , Ji Young(홍지영)
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