Cited 45 times in
Adjunctive biomarkers for improving diagnosis of tuberculosis and monitoring therapeutic effects.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김아름 | - |
dc.contributor.author | 김영미 | - |
dc.contributor.author | 이상아 | - |
dc.contributor.author | 장선희 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 허윤경 | - |
dc.contributor.author | 홍지영 | - |
dc.date.accessioned | 2016-02-04T11:01:04Z | - |
dc.date.available | 2016-02-04T11:01:04Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139481 | - |
dc.description.abstract | OBJECTIVES: To identify host biomarkers associated with latent tuberculosis infection (LTBI), active tuberculosis (TB), and nontuberculous mycobacteria (NTM) diseases to improve diagnosis and effective anti-TB treatment. METHODS: Active TB and NTM patients at diagnosis, recent TB contacts, and normal healthy subjects were recruited. Tuberculin skin tests, QuantiFERON-TB Gold In-Tube tests, and multiplex bead arrays with 17 analytes were performed. TB patients were re-evaluated after 2 and 6 months of treatment. RESULTS: Mycobacterium tuberculosis (M. tb) antigen-specific IFN-γ, IL-2, and CXCL10 responses were significantly higher in active TB and LTBI compared with controls (P < 0.01). Only serum VEGF levels varied between the active TB and LTBI groups (AUC = 0.7576, P < 0.001). Active TB and NTM diseases were differentiated by serum IL-2, IL-9, IL-13, IL-17, TNF-α and sCD40L levels (P < 0.05). Increased sCD40L and decreased M. tb antigen-specific IFN-γ levels correlated with sputum clearance of M. tb after 2 months of treatment (P < 0.001). CONCLUSIONS: Serum IL-2, IL-9, IL-13, IL-17, TNF-α, sCD40L and VEGF-A levels may be adjunctive biomarkers for differential diagnosis of active TB, LTBI, and NTM disease. Assessment of serum sCD40L and M. tb antigen-specific IFN-γ, TNF-α, and IL-2 levels could help predict successful anti-TB treatment in conjunction with M. tb clearance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 346~355 | - |
dc.relation.isPartOf | JOURNAL OF INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antitubercular Agents/therapeutic use | - |
dc.subject.MESH | Biomarkers/blood* | - |
dc.subject.MESH | Chemokine CXCL10/blood | - |
dc.subject.MESH | Cytokines/blood | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Tests | - |
dc.subject.MESH | Interferon-gamma/blood | - |
dc.subject.MESH | Interleukin-2 | - |
dc.subject.MESH | Latent Tuberculosis/diagnosis* | - |
dc.subject.MESH | Latent Tuberculosis/drug therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous/diagnosis* | - |
dc.subject.MESH | Reagent Kits, Diagnostic | - |
dc.subject.MESH | Tuberculin Test | - |
dc.subject.MESH | Tuberculosis/diagnosis* | - |
dc.subject.MESH | Tuberculosis/therapy* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/blood* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Adjunctive biomarkers for improving diagnosis of tuberculosis and monitoring therapeutic effects. | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Family Health Care (간호환경시스템학과) | - |
dc.contributor.googleauthor | Yun Gyoung Hur | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Sun Hee Jang | - |
dc.contributor.googleauthor | Ji Young Hong | - |
dc.contributor.googleauthor | Ahreum Kim | - |
dc.contributor.googleauthor | Sang A Lee | - |
dc.contributor.googleauthor | Youngmi Kim | - |
dc.contributor.googleauthor | Sang Nae Cho | - |
dc.identifier.doi | 10.1016/j.jinf.2014.10.019 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00705 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00679 | - |
dc.contributor.localId | A02818 | - |
dc.contributor.localId | A03435 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A04441 | - |
dc.contributor.localId | A04701 | - |
dc.relation.journalcode | J01452 | - |
dc.identifier.eissn | 1532-2742 | - |
dc.identifier.pmid | 25452040 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S016344531400334X | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | Diagnosis | - |
dc.subject.keyword | Latent tuberculosis infection (LTBI) | - |
dc.subject.keyword | Mycobacterium tuberculosis (M. tb) | - |
dc.subject.keyword | Nontuberculous mycobacteria (NTM) | - |
dc.subject.keyword | Treatment | - |
dc.subject.keyword | Tuberculosis (TB) | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Ah Reum | - |
dc.contributor.alternativeName | Kim, Young Mi | - |
dc.contributor.alternativeName | Lee, Sang A | - |
dc.contributor.alternativeName | Jang, Sun Hee | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Hur, Yun Gyoung | - |
dc.contributor.alternativeName | Hong, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Young Mi | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Ah Reum | - |
dc.contributor.affiliatedAuthor | Lee, Sang A | - |
dc.contributor.affiliatedAuthor | Jang, Sun Hee | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Hong , Ji Young | - |
dc.contributor.affiliatedAuthor | Hur, Yun-Gyoung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 70 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 346 | - |
dc.citation.endPage | 355 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION, Vol.70(4) : 346-355, 2015 | - |
dc.identifier.rimsid | 55422 | - |
dc.type.rims | ART | - |
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