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The cholesterol-lowering effect of plant sterol-containing beverage in hypercholesterolemic subjects with low cholesterol intake

Authors
 Min-Jeong Shin  ;  Se-Joong Rim  ;  Namsik Chung  ;  Kijun Song  ;  Dong Kee Kim  ;  Sung-Soon Kim  ;  Seung-Yun Cho  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Yangsoo Jang 
Citation
 NUTRITION RESEARCH, Vol.23(4) : 489-496, 2003 
Journal Title
 NUTRITION RESEARCH 
ISSN
 0271-5317 
Issue Date
2003
MeSH
Phytosterols ; Cholesterol ; LDL-cholesterol
Keywords
Phytosterols ; Cholesterol ; LDL-cholesterol
Abstract
We investigated the effect of a beverage containing plant sterols on serum concentrations of triacylglycerol and cholesterol of hypercholesterolemic subjects that consume a low cholesterol diet. Fifty three hypercholesterolemic subjects (fasting LDL-cholesterol > 130 mg/dl) were fed a placebo beverage for 4 weeks followed by feeding a test beverage containing plant sterols for 8 weeks in a single-blind, randomized cross-over study. The subjects were instructed to maintain the same amount of dietary intake of fat and cholesterol during the study. After 4 weeks of treatment with a beverage containing of 1.6 g/d of plant sterols, subjects whose concentrations of LDL-cholesterol did not decrease by 15% received 3.2 g/d of plant sterols. The total study population who completed the whole protocol was 45 subjects (15 males, 30 females, average age 56). At baseline, the average dietary daily intakes of saturated fat and cholesterol were relatively low with 11.12 g and 135.2 mg, respectively. After 8 week treatment with plant sterols, serum concentrations of total cholesterol and LDL-cholesterol were decreased significantly by 4.38% (p < 0.05), 8.28% (p < 0.05) respectively. However, concentrations of HDL-cholesterol and triacylglycerol did not change significantly. We conclude that a beverage containing plant sterols decrease serum total cholesterol and LDL-cholesterol concentrations significantly in subjects with relatively low dietary cholesterol intake.
Full Text
http://www.sciencedirect.com/science/article/pii/S0271531703000162
DOI
10.1016/S0271-5317(03)00016-2
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Shin, Min Jeong(신민정)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114375
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