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Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery

Authors
 Jaemoon Yang  ;  Eun-Jin Cho  ;  Sungbaek Seo  ;  Jae-Won Lee  ;  Ho-Geun Yoon  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.84(1) : 273-280, 2008 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 
ISSN
 1549-3296 
Issue Date
2008
MeSH
Cell Line, Tumor ; Cell Survival/drug effects ; Chemical Phenomena ; Chemistry, Physical ; Drug Delivery Systems* ; Humans ; Magnetic Resonance Spectroscopy ; Microscopy, Electron, Transmission ; Molecular Structure ; Molecular Weight ; Nanoparticles/chemistry* ; Nanoparticles/toxicity* ; Nanoparticles/ultrastructure ; Polyethylene Glycols/chemistry* ; Polyethylene Glycols/toxicity*
Keywords
folate ; polyethylene glycol ; poly e-caprolactone diol ; doxorubicin ; nanoparticle
Abstract
Folate (FA) conjugated tri-block copolymers were prepared by bioconjugation of poly epsilon-caprolactonediol and various molecular weights of diamine polyethylene glycol. The synthetic tri-block copolymers were characterized by 1H-NMR. Three types of nanoparticles were prepared by nanoprecipitation. Their size and morphology were verified by laser scattering and transmission electron microscopy, respectively. The colloidal stability of the nanoparticles was evaluated by turbidity test. The anticancer drug doxorubicin (DOX) was encapsulated in the nanoparticles during preparation. Drug loading amounts and release behavior from prepared nanoparticles were investigated. Fluorescent-activated cell sorting analysis and epi-fluorescencic microscopic imaging of prepared nanoparticles exhibited good cellular uptake against target cells. FA receptor expressed OVCAR3 cells that showed higher mean fluorescence intensity than FA receptor defect A549 cells at specific polyethylene glycol chain lengths. The cell cytotoxicity of prepared nanoparticles was evaluated for receptor mediated drug delivery
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.31312/abstract
DOI
10.1002/jbm.a.31312
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108218
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