Cited 21 times in
Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-05-19T17:28:34Z | - |
dc.date.available | 2015-05-19T17:28:34Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108218 | - |
dc.description.abstract | Folate (FA) conjugated tri-block copolymers were prepared by bioconjugation of poly epsilon-caprolactonediol and various molecular weights of diamine polyethylene glycol. The synthetic tri-block copolymers were characterized by 1H-NMR. Three types of nanoparticles were prepared by nanoprecipitation. Their size and morphology were verified by laser scattering and transmission electron microscopy, respectively. The colloidal stability of the nanoparticles was evaluated by turbidity test. The anticancer drug doxorubicin (DOX) was encapsulated in the nanoparticles during preparation. Drug loading amounts and release behavior from prepared nanoparticles were investigated. Fluorescent-activated cell sorting analysis and epi-fluorescencic microscopic imaging of prepared nanoparticles exhibited good cellular uptake against target cells. FA receptor expressed OVCAR3 cells that showed higher mean fluorescence intensity than FA receptor defect A549 cells at specific polyethylene glycol chain lengths. The cell cytotoxicity of prepared nanoparticles was evaluated for receptor mediated drug delivery | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 273~280 | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Chemical Phenomena | - |
dc.subject.MESH | Chemistry, Physical | - |
dc.subject.MESH | Drug Delivery Systems* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Molecular Structure | - |
dc.subject.MESH | Molecular Weight | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Nanoparticles/toxicity* | - |
dc.subject.MESH | Nanoparticles/ultrastructure | - |
dc.subject.MESH | Polyethylene Glycols/chemistry* | - |
dc.subject.MESH | Polyethylene Glycols/toxicity* | - |
dc.title | Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Eun-Jin Cho | - |
dc.contributor.googleauthor | Sungbaek Seo | - |
dc.contributor.googleauthor | Jae-Won Lee | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/jbm.a.31312 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J01266 | - |
dc.identifier.eissn | 1552-4965 | - |
dc.identifier.pmid | 17688283 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.31312/abstract | - |
dc.subject.keyword | folate | - |
dc.subject.keyword | polyethylene glycol | - |
dc.subject.keyword | poly e-caprolactone diol | - |
dc.subject.keyword | doxorubicin | - |
dc.subject.keyword | nanoparticle | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 84 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 273 | - |
dc.citation.endPage | 280 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.84(1) : 273-280, 2008 | - |
dc.identifier.rimsid | 35256 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.