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Nerve growth factor and expression of its receptors in patients with diabetic neuropathy

Authors
 H. C. Kim  ;  Y. J. Cho  ;  C. W. Ahn  ;  K. S. Park  ;  J. C. Kim  ;  J. S. Nam  ;  Y. S. Im  ;  J. E. Lee  ;  S. C. Lee  ;  H. K. Lee 
Citation
 Diabetic Medicine, Vol.26(12) : 1228-1234, 2009 
Journal Title
 Diabetic Medicine 
ISSN
 0742-3071 
Issue Date
2009
Abstract
AIMS: Low serum nerve growth factor (NGF) levels have been reported in patients with diabetic peripheral neuropathy (DPN), but the role of NGF in the development of neuropathy is unclear. Thus, we investigated the associations of serum NGF level and NGF receptor activity with the presence and severity of DPN. METHODS: One hundred and thirty-six patients with Type 2 diabetes were included in this cross-sectional study. Serum NGF levels were measured by ELISA. Expressions of NGF receptors (TrkA and p75(NTR)) were measured by immunohistochemical staining. The presence and severity of DPN were assessed by neuropathy disability score (NDS) and by corneal nerve fibre length (cNFL) and nerve branch density (cNBD) using in vivo confocal microscopy. RESULTS: Patients with DPN had higher serum NGF levels (56-451 pg/ml) than patients without DPN (4-54 pg/ml). However, in DPN patients, serum NGF was negatively associated with neuropathy severity (mild 222 +/- 64 pg/ml; moderate 114 +/- 17 pg/ml; severe 89 +/- 20 pg/ml). This negative association was consistent in all severity indices (NDS, P < 0.001; cNFL, P < 0.001; cNBD P = 0.010) even after adjustment for age, sex, diabetes duration, insulin use, fasting glucose and glycated haemoglobin. Although NGF receptor activities had significantly (P < 0.05) negative associations with the presence and severity of neuropathy, these associations were not significant when adjusted for other factors. CONCLUSIONS: Serum NGF level was positively associated with the presence of DPN but negatively associated with neuropathy severity in DPN patients. The change in serum NGF might be a consequence of, rather than a contributor to, the early development of DPN
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2009.02856.x/abstract
DOI
10.1111/j.1464-5491.2009.02856.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
남지선(Nam, Ji Sun) ORCID logo https://orcid.org/0000-0001-8655-5258
박경수(Park, Kyungsoo) ORCID logo https://orcid.org/0000-0002-6972-1143
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
이성철(Lee, Sung Chul) ORCID logo https://orcid.org/0000-0001-9438-2385
이종은(Lee, Jong Eun) ORCID logo https://orcid.org/0000-0001-6203-7413
이형근(Lee, Hyung Keun) ORCID logo https://orcid.org/0000-0002-1123-2136
임영선(Im, Young Sun)
조영재(Cho, Young Jae)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105546
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