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유치의 치수와 치주인대에서 분리한 줄기세포의 특성

Other Titles
 Characterization of Stem Cells Obtained from the Dental Pulp and Periodontal Ligament of Deciduous Teeth 
Authors
 송제선  ;  김승혜  ;  김성오  ;  최병재  ;  김정희  ;  곽성욱  ;  정한성 
Citation
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.7(5) : 575-582, 2010 
Journal Title
 Tissue Engineering and Regenerative Medicine  (조직공학과 재생의학) 
ISSN
 1738-2696 
Issue Date
2010
Abstract
Many studies have found adult stem cells in human teeth or correlated tissues. However, most of these stem cells were found in the permanent teeth or pulp from exfoliated deciduous teeth. The aim of the present study was to characterize stem cells isolated from the functional dental pulp and periodontal ligament of deciduous teeth. Dental pulp tissue was obtained from deciduous teeth by extirpation during treatment for dental caries, and periodontal tissue was obtained from deciduous teeth that were extracted for orthodontic reasons or space management. We observed cell outgrowth from these tissues in ‘explants culture’, and named these cells as deciduous dental pulp stem cells (DDPSCs) and deciduous periodontal ligament stem cells (DPDLSCs), respectively. These stem cells presented embryonic stem cell markers (Oct-4 and Nanog), an ectomesenchymal stem cell marker (Nestin), and mesenchymal stem cell markers (Stro-1 and CD146). In differentiation media, DDPSCs and DPDLSCs were able to change into cells that produce lipid vacuoles or cells that induce extracellular mineral aggregation, expressing genes correlated with adipogenesis (PPARγ2 and LPL) or osteogenesis (ALP and BSP), respectively. This is the first report of the presence of multipotent stem cells in the functional dental pulp and periodontal ligament tissue of deciduous teeth, which can be isolated using an explants culture method. These tissues can be obtained easily during routine dental procedures, and could therefore represent a good source of adult stem cells for use in regenerative medicine
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Sung Wook(곽성욱)
Kim, Seong Oh(김성오) ORCID logo https://orcid.org/0000-0002-8620-1377
Kim, Seung Hye(김승혜)
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Choi, Byung Jai(최병재)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102486
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