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Pattern of failure in bladder cancer patients treated with radical cystectomy: rationale for adjuvant radiotherapy

Authors
 Yong Bae Kim  ;  Sung Joon Hong  ;  Seung Cheol Yang  ;  Jae Ho Cho  ;  Young Deuk Choi  ;  Gwi Eon Kim  ;  Koon Ho Rha  ;  Woong Kyu Han  ;  Nam Hoon Cho  ;  Young Taek Oh 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(6) : 835-840, 2010 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2010
MeSH
Adult ; Aged ; Aged, 80 and over ; Cystectomy* ; Data Interpretation, Statistical ; Disease-Free Survival ; Female ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Radiotherapy, Adjuvant ; Survival Rate ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/mortality ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/therapy*
Keywords
Pelvic Failure ; Radical Cystectomy ; Radiotherapy ; Adjuvant ; Urinary Bladder Neopla는
Abstract
Thus far, the role of adjuvant radiotherapy (RT) after radical cystectomy (RC) in urinary bladder cancer patients has yet to be defined. The purpose of this study is to analyze patterns of failure, and suggest the rationale for RT. Between 1986 and 2005, a total of 259 patients treated with RC and pelvic lymph node dissection was enrolled. The age range was 27-82 yr (median, 62 yr). Node positivity increased according to tumor staging. Patients were divided into the following two groups based on pathologic analysis: organ-confined disease group (n=135) and extravesical/lymph node-positive disease group (n=80). Pelvic failures (PF) were observed in 8 (4.9%) in organ-confined disease group, and 21 (21.7%) in extravesical/lymph node-positive disease group. Five-year PF-free survival rates were 91.2% in organ-confined disease group and 68.0% in extravesical/lymph node-positive disease group. Five-year cancer-specific survival rates were 86.2% in organ-confined disease group and 53.9% in extravesical/lymph node-positive disease group. In conclusion, a relatively high PF rate was observed in extravesical lymph node-negative and lymph node-positive disease patients in this study. Adjuvant pelvic RT may be considered to reduce pelvic failures in extravesical lymph node-positive bladder cancer. Future prospective trials are required to test the clinical benefit of adjuvant RT.
Files in This Item:
T201002403.pdf Download
DOI
10.3346/jkms.2010.25.6.835
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Yang, Seung Choul(양승철)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101558
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