Browsing by Yonsei Author : Cho, Jae Ho

eperson profile image
Name :
Cho, Jae Ho [조재호]
orcid http://orcid.org/0000-0001-9966-5157
Department :
College of Medicine (의과대학) - Dept. of Radiation Oncology (방사선종양학교실)
Scopus ID :
Scopus (55231352500)

교수 기본정보

세부 전공
전립선암, 폐암, 방사선생물학
이메일
JJHMD@yuhs.ac

실험실 기본정보

이름
분자방사선생물학 실험실
위치
ABMRC 401호
구분
Wet Lab (100%), Dry Lab ( %)

연구소개

연구 분야
연구 내용
저의 연구는 방사선 치료 과정에서 발생하는 정상조직 손상의 생물학적 기전 규명을 출발점으로 하여, 이를 정량적으로 모델링하고, 예방 및 치료 전략으로 연결하는 전주기적(translational) 연구를 목표로 하고 있습니다.
특히 방사선으로 유발되는 폐 손상, 즉 **방사선폐렴(radiation pneumonitis)**과 **방사선유발 폐섬유화(radiation-induced pulmonary fibrosis)**를 중심으로, 염증–면역 반응, 섬유화 신호전달 경로, 세포 간 상호작용을 규명해 왔습니다. 이러한 연구는 전임상 동물모델과 세포 실험뿐 아니라, 임상 방사선치료 데이터와의 연계를 통해 실제 환자 치료에 적용 가능한 기전 중심 연구로 확장되고 있습니다.
아울러, 방사선 손상과 병태생리적 연속성을 지니는 **특발성 폐섬유증(idiopathic pulmonary fibrosis)**에 대해서도 연구를 병행하며, 방사선 손상 연구에서 얻은 기전적 통찰을 비방사선성 폐섬유화 질환으로 확장 적용하는 데에도 관심을 두고 있습니다.

임상적으로는 전립선암 및 폐암에서 방사선치료와 관련한 임상연구를 수행할 수도 있습니다.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 1. 기초·중개 연구 분야
  • - 방사선 조사 후 폐 조직에서 염증 및 섬유화 관련 신호전달 경로 분석
  • - 방사선폐렴/폐섬유화 모델에서 면역세포(T cell, macrophage) 역할 규명
  • - 방사선 유발 정상조직 손상에서 예방·치료 후보물질의 효과 평가
  • 2. 임상 연구
  • - 전립선암 방사선치료에서의 치료 최적화 및 부작용 최소화 전략
  • - 폐암 방사선치료 임상 결과, 치료법, 부작용 등 연구
  • ▷ 연구계획서 작성
학생 참여 시 사용하게 되는 장비 및 프로그램
  • - 임상 데이터베이스 및 EMR 기반 연구
  • - 방사선 조사 장비 (소동물 방사선 조사 시스템)
  • - 세포 배양 시스템 (CO₂ incubator, biosafety cabinet)
  • - 동물 실험 플랫폼 (폐 손상·섬유화 모델)
  • - 분자생물학 기법 - Western blot, qPCR, ELISA, Immunohistochemistry / Immunofluorescence
참여 전 준비사항
  • 없음

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Issue DateTitleJournal Title
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