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Reduced serum total osteocalcin is associated with central obesity in Korean children

 Gwang Suk Kim  ;  Yoonsuk Jekal  ;  Hee Soon Kim  ;  Jee-Aee Im  ;  Ji Young Park  ;  Sang Hui Chu 
 Obesity Research & Clinical Practice, Vol.8 : 230-237, 2014 
Journal Title
 Obesity Research & Clinical Practice 
Issue Date
BACKGROUND: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. METHODS: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m(2)) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. RESULTS: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. CONCLUSIONS: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.
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3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
김광숙(Kim, Gwang Suk) ORCID logo https://orcid.org/0000-0001-9823-6107
김희순(Kim, Hee Soon) ORCID logo https://orcid.org/0000-0001-6656-0308
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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