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Reduced serum total osteocalcin is associated with central obesity in Korean children

DC FieldValueLanguage
dc.contributor.author김광숙-
dc.contributor.author김희순-
dc.contributor.author추상희-
dc.date.accessioned2015-01-06T16:43:25Z-
dc.date.available2015-01-06T16:43:25Z-
dc.date.issued2014-
dc.identifier.issn1871-403X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98642-
dc.description.abstractBACKGROUND: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. METHODS: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m(2)) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. RESULTS: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. CONCLUSIONS: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.-
dc.description.statementOfResponsibilityopen-
dc.format.extente230~e237-
dc.relation.isPartOfOBESITY RESEARCH & CLINICAL PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlood Glucose/metabolism*-
dc.subject.MESHBody Mass Index-
dc.subject.MESHC-Reactive Protein/metabolism*-
dc.subject.MESHChild-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHLipids/blood*-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood*-
dc.subject.MESHMetabolic Syndrome/epidemiology-
dc.subject.MESHMetabolic Syndrome/prevention & control-
dc.subject.MESHObesity, Abdominal/blood*-
dc.subject.MESHObesity, Abdominal/epidemiology-
dc.subject.MESHObesity, Abdominal/prevention & control-
dc.subject.MESHOsteocalcin/blood*-
dc.subject.MESHOsteocalcin/deficiency-
dc.subject.MESHPhenotype-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHWaist Circumference-
dc.titleReduced serum total osteocalcin is associated with central obesity in Korean children-
dc.typeArticle-
dc.contributor.collegeCollege of Nursing (간호대학)-
dc.contributor.departmentDept. of Clinical Nursing (가족건강관리학과)-
dc.contributor.googleauthorGwang Suk Kim-
dc.contributor.googleauthorYoonsuk Jekal-
dc.contributor.googleauthorHee Soon Kim-
dc.contributor.googleauthorJee-Aee Im-
dc.contributor.googleauthorJi Young Park-
dc.contributor.googleauthorSang Hui Chu-
dc.identifier.doi10.1016/j.orcp.2012.12.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00314-
dc.contributor.localIdA01212-
dc.contributor.localIdA04232-
dc.relation.journalcodeJ02406-
dc.identifier.pmid24847664-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1871403X12002712-
dc.subject.keywordOsteocalcin-
dc.subject.keywordObesity-
dc.subject.keywordChildren-
dc.contributor.alternativeNameKim, Gwang Suk-
dc.contributor.alternativeNameKim, Hee Soon-
dc.contributor.alternativeNameChoo, Sang Hee-
dc.contributor.affiliatedAuthorKim, Gwang Suk-
dc.contributor.affiliatedAuthorKim, Hee Soon-
dc.contributor.affiliatedAuthorChoo, Sang Hee-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.startPage230-
dc.citation.endPage237-
dc.identifier.bibliographicCitationOBESITY RESEARCH & CLINICAL PRACTICE, Vol.8 : 230-237, 2014-
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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