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Intraindividual Comparison of Diagnostic Performance in Patients With Hepatic Metastasis of Full-Dose Standard and Half-Dose Iterative Reconstructions With Dual-Source Abdominal Computed Tomography

 Mina Park  ;  Yong Eun Chung  ;  Hye Sun Lee  ;  Jin-Young Choi  ;  Mi-Suk Park  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
 Investigative Radiology, Vol.49(4) : 195-200, 2014 
Journal Title
 Investigative Radiology 
Issue Date
OBJECTIVES: The objectives of the study were to evaluate the image quality and diagnostic performance of sinogram-affirmed iterative reconstruction (SAFIRE) for detecting hepatic metastasis and to estimate the potential radiation dose reduction at abdominal computed tomography (CT). MATERIALS AND METHODS: Fifty-nine consecutive patients (mean age, 59.2 years; range, 42-81 years) who had hepatic metastasis and who underwent dual-source abdominal CT were enrolled in this study. The image noise of the liver was compared between full-dose filtered back projection images (FD-FBP) and simulated half-dose images, which used only single-source projection data, and reconstructed with different strengths of SAFIRE (HD-SAFIRE(1-5)) by 1-way analysis of variance with Bonferroni correction. The diagnostic performance for hepatic metastasis was compared by logistic regression with the weighted least squares method and noninferiority test between the FD-FBP images and the half-dose sinogram-affirmed iterative reconstruction (HD-SAFIRE) images. RESULTS: As the SAFIRE strength increased, image noise decreased (P < 0.001). The images of HD-SAFIRE(2) showed similar image noise for liver parenchyma (13.4 Hounsfield unit [HU]), signal-to-noise ratio for liver parenchyma (9.2), and lesion-to-liver contrast-to-noise ratio (4.5), compared with the FD-FBP images (12.6 HU, P = 0.668; 9.6, P > 0.999; and 4.5, P > 0.999, respectively). The diagnostic accuracy for hepatic metastasis with the HD-SAFIRE(2) images (87.5%) was not different from that of the FD-FBP images (87.5%, P > 0.999). The diagnostic performance of the HD-SAFIRE(2) images was also noninferior to that of the FD-FBP images (95% confidence interval lower limit difference [-9.16%] excluding the -10% clinical noninferiority limit). The mean (SD) volume CT dose index of FD-FBP was 11.26 (2.66) mGy, and the mean (SD) radiation dose equivalent associated with HD-SAFIRE was estimated to be 5.63 (1.33) mGy. CONCLUSIONS: By applying SAFIRE2, the radiation dose could be reduced by up to 50% compared with the standard-of-care abdominal CT protocol without increasing image noise and without deteriorating diagnostic performance for the detection of hepatic metastasis.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김기황(Kim, Ki Whang)
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
박미나(Park, Mina) ORCID logo https://orcid.org/0000-0002-2005-7560
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
정용은(Chung, Yong Eun) ORCID logo https://orcid.org/0000-0003-0811-9578
최진영(Choi, Jin Young) ORCID logo https://orcid.org/0000-0002-9025-6274
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