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Intraindividual Comparison of Diagnostic Performance in Patients With Hepatic Metastasis of Full-Dose Standard and Half-Dose Iterative Reconstructions With Dual-Source Abdominal Computed Tomography

Authors
 Mina Park  ;  Yong Eun Chung  ;  Hye Sun Lee  ;  Jin-Young Choi  ;  Mi-Suk Park  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
Citation
 INVESTIGATIVE RADIOLOGY, Vol.49(4) : 195-200, 2014 
Journal Title
INVESTIGATIVE RADIOLOGY
ISSN
 0020-9996 
Issue Date
2014
MeSH
Adult ; Aged ; Female ; Humans ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/secondary* ; Male ; Middle Aged ; Observer Variation ; Radiation Dosage* ; Radiation Protection/methods* ; Radiographic Image Enhancement/methods ; Radiographic Image Interpretation, Computer-Assisted/methods* ; Radiography, Abdominal/methods ; Radiography, Dual-Energy Scanned Projection/methods* ; Radiometry ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods*
Keywords
iterative reconstruction ; abdominal CT scan ; radiation dose ; hepatic metastasis ; image noise
Abstract
OBJECTIVES:
The objectives of the study were to evaluate the image quality and diagnostic performance of sinogram-affirmed iterative reconstruction (SAFIRE) for detecting hepatic metastasis and to estimate the potential radiation dose reduction at abdominal computed tomography (CT).
MATERIALS AND METHODS:
Fifty-nine consecutive patients (mean age, 59.2 years; range, 42-81 years) who had hepatic metastasis and who underwent dual-source abdominal CT were enrolled in this study. The image noise of the liver was compared between full-dose filtered back projection images (FD-FBP) and simulated half-dose images, which used only single-source projection data, and reconstructed with different strengths of SAFIRE (HD-SAFIRE(1-5)) by 1-way analysis of variance with Bonferroni correction. The diagnostic performance for hepatic metastasis was compared by logistic regression with the weighted least squares method and noninferiority test between the FD-FBP images and the half-dose sinogram-affirmed iterative reconstruction (HD-SAFIRE) images.
RESULTS:
As the SAFIRE strength increased, image noise decreased (P < 0.001). The images of HD-SAFIRE(2) showed similar image noise for liver parenchyma (13.4 Hounsfield unit [HU]), signal-to-noise ratio for liver parenchyma (9.2), and lesion-to-liver contrast-to-noise ratio (4.5), compared with the FD-FBP images (12.6 HU, P = 0.668; 9.6, P > 0.999; and 4.5, P > 0.999, respectively). The diagnostic accuracy for hepatic metastasis with the HD-SAFIRE(2) images (87.5%) was not different from that of the FD-FBP images (87.5%, P > 0.999). The diagnostic performance of the HD-SAFIRE(2) images was also noninferior to that of the FD-FBP images (95% confidence interval lower limit difference [-9.16%] excluding the -10% clinical noninferiority limit). The mean (SD) volume CT dose index of FD-FBP was 11.26 (2.66) mGy, and the mean (SD) radiation dose equivalent associated with HD-SAFIRE was estimated to be 5.63 (1.33) mGy.
CONCLUSIONS:
By applying SAFIRE2, the radiation dose could be reduced by up to 50% compared with the standard-of-care abdominal CT protocol without increasing image noise and without deteriorating diagnostic performance for the detection of hepatic metastasis.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004424-201404000-00002&LSLINK=80&D=ovft
DOI
10.1097/RLI.0000000000000014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98639
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