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Efficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer

Authors
 Seung Woo Yi  ;  Dae Ryong Kang  ;  Kyung Sik Kim  ;  Mi Suk Park  ;  Jinsil Seong  ;  Jeong Youp Park  ;  Seung Min Bang  ;  Si Young Song  ;  Jae Bock Chung  ;  Seung Woo Park 
Citation
 Cancer Chemotherapy and Pharmacology, Vol.73(1) : 191-198, 2014 
Journal Title
 Cancer Chemotherapy and Pharmacology 
ISSN
 0344-5704 
Issue Date
2014
Abstract
PURPOSE: There is no established standard treatment for patients with locally advanced biliary tract cancer (BTC). METHODS: We analyzed the treatment results of locally advanced BTC from Jan 1995 to Dec 2010 at single institution of South Korea with retrospective study. One hundred and seventy-six patients were eligible to investigate the treatment response and toxicity. We treated these patients with 5-fluorouracil (5-FU)- or gemcitabine (GEM)-based concurrent chemoradiotherapy (CCRT) or best supportive care (BSC). The primary end point was overall survival. RESULTS: Of these locally advanced BTC patients, 106 patients received CCRT and 70 patients were treated with BSC. The median overall survival was 42.57 weeks (95 % confidence interval [CI], 35.85-49.30) in CCRT group and 13.29 weeks (95 % CI 10.42-16.15) in BSC group (P < 0.001). Nausea and anemia were the most common toxicities observed. CONCLUSIONS: Patients with locally advanced BTC who were treated with 5-FU-based or GEM-based CCRT seem to have a better survival than those who received BSC. The treatment-related toxicity was mild. GEM-based or 5-FU-based CCRT showed similar survival advantages.
Full Text
http://link.springer.com/article/10.1007%2Fs00280-013-2340-5
DOI
10.1007/s00280-013-2340-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
강대용(Kang, Dae Ryong)
김경식(Kim, Kyung Sik) ORCID logo https://orcid.org/0000-0001-9498-284X
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
박승우(Park, Seung Woo) ORCID logo https://orcid.org/0000-0001-8230-964X
박정엽(Park, Jeong Youp) ORCID logo https://orcid.org/0000-0003-0110-8606
방승민(Bang, Seungmin) ORCID logo https://orcid.org/0000-0001-5209-8351
성진실(Seong, Jin Sil) ORCID logo https://orcid.org/0000-0003-1794-5951
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
이승우(Yi, Seung Woo) ORCID logo https://orcid.org/0000-0002-5929-9444
정재복(Chung, Jae Bock)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98008
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