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Efficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer

DC FieldValueLanguage
dc.contributor.author강대용-
dc.contributor.author김경식-
dc.contributor.author박미숙-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author성진실-
dc.contributor.author송시영-
dc.contributor.author이승우-
dc.contributor.author정재복-
dc.date.accessioned2015-01-06T16:23:08Z-
dc.date.available2015-01-06T16:23:08Z-
dc.date.issued2014-
dc.identifier.issn0344-5704-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98008-
dc.description.abstractPURPOSE: There is no established standard treatment for patients with locally advanced biliary tract cancer (BTC). METHODS: We analyzed the treatment results of locally advanced BTC from Jan 1995 to Dec 2010 at single institution of South Korea with retrospective study. One hundred and seventy-six patients were eligible to investigate the treatment response and toxicity. We treated these patients with 5-fluorouracil (5-FU)- or gemcitabine (GEM)-based concurrent chemoradiotherapy (CCRT) or best supportive care (BSC). The primary end point was overall survival. RESULTS: Of these locally advanced BTC patients, 106 patients received CCRT and 70 patients were treated with BSC. The median overall survival was 42.57 weeks (95 % confidence interval [CI], 35.85-49.30) in CCRT group and 13.29 weeks (95 % CI 10.42-16.15) in BSC group (P < 0.001). Nausea and anemia were the most common toxicities observed. CONCLUSIONS: Patients with locally advanced BTC who were treated with 5-FU-based or GEM-based CCRT seem to have a better survival than those who received BSC. The treatment-related toxicity was mild. GEM-based or 5-FU-based CCRT showed similar survival advantages.-
dc.description.statementOfResponsibilityopen-
dc.format.extent191~198-
dc.relation.isPartOfCancer Chemotherapy and Pharmacology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAntimetabolites, Antineoplastic/therapeutic use*-
dc.subject.MESHBiliary Tract Neoplasms/mortality-
dc.subject.MESHBiliary Tract Neoplasms/therapy*-
dc.subject.MESHChemoradiotherapy*/adverse effects-
dc.subject.MESHDeoxycytidine/adverse effects-
dc.subject.MESHDeoxycytidine/analogs & derivatives*-
dc.subject.MESHDeoxycytidine/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil/adverse effects-
dc.subject.MESHFluorouracil/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleEfficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung Woo Yi-
dc.contributor.googleauthorDae Ryong Kang-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorMi Suk Park-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeung Min Bang-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJae Bock Chung-
dc.contributor.googleauthorSeung Woo Park-
dc.identifier.doi10.1007/s00280-013-2340-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA01463-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA01956-
dc.contributor.localIdA02035-
dc.contributor.localIdA02920-
dc.contributor.localIdA03706-
dc.contributor.localIdA00009-
dc.relation.journalcodeJ00437-
dc.identifier.pmid24322374-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00280-013-2340-5-
dc.subject.keywordBiliary tract cancer-
dc.subject.keywordConcurrent chemoradiation-
dc.subject.keywordGB cancer-
dc.subject.keywordLocally advanced-
dc.contributor.alternativeNameKang, Dae Ryong-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameYi, Seung Woo-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorYi, Seung Woo-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.contributor.affiliatedAuthorKang, Dae Ryong-
dc.rights.accessRightsfree-
dc.citation.volume73-
dc.citation.number1-
dc.citation.startPage191-
dc.citation.endPage198-
dc.identifier.bibliographicCitationCancer Chemotherapy and Pharmacology, Vol.73(1) : 191-198, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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