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Comparison of association of glomerular filtration rate with metabolic syndrome in a community-based population using the CKD-EPI and MDRD study equations.

 Namki Hong  ;  Jaewon Oh  ;  Yong-ho Lee  ;  Jong Chan Youn  ;  Sungha Park  ;  Sang-Hak Lee  ;  Yangsoo Jang  ;  Namsik Chung  ;  Soyoon Kim  ;  Sun Ha Jee  ;  Seok-Min Kang 
 CLINICA CHIMICA ACTA, Vol.429 : 157-162, 2014 
Journal Title
Issue Date
Adult ; Aged ; Data Collection* ; Female ; Glomerular Filtration Rate* ; Humans ; Male ; Metabolic Syndrome/complications* ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/physiopathology* ; Middle Aged ; Prognosis ; Renal Insufficiency, Chronic/complications* ; Renal Insufficiency, Chronic/epidemiology* ; Residence Characteristics/statistics & numerical data* ; Risk Factors
Chronic kidney disease ; Kidney function ; Metabolic syndrome
BACKGROUND: Targeting metabolic syndrome (MetS) in early chronic kidney disease (CKD) is essential to reduce cardiovascular complications. We compared the association of kidney function estimated by two glomerular filtration rate (GFR) equations with MetS in community population. METHODS: We analyzed 12,700 participants from 2009 to 2010 the Korea National Health Survey data. GFR was estimated using the CKD Epidemiology Collaboration equation (GFR(CKD-EPI)) and the Modification of Diet in Renal Disease study equation (GFR(MDRD)). RESULTS: The prevalence of MetS increased from the highest GFR category (>105 ml/min/1.73 m(2)) to the lowest (<60 ml/min/1.73 m(2)) using both equations (GFR(CKD-EPI), 14.1% to 62.3%; GFR(MDRD), 18.4% to 62.9%). Participants reclassified to higher GFR(CKD-EPI) category (upward) from GFR(MDRD) had lower prevalence of MetS than those moved downward (Net reclassification improvement 13.7%, P<0.001). Compared with GFR ≥105 ml/min/1.73 m(2), mildly impaired GFR(CKD-EPI) (75-89 ml/min/1.73 m(2)) was independently associated with increased odds of MetS (OR 1.30, 95% CI 1.09-1.56, P=0.003) in multivariate analysis, whereas GFR(MDRD) was not (OR 1.08, 95% CI 0.92-1.27, P=0.344). CONCLUSIONS: Compared with GFR(MDRD), GFR(CKD-EPI) showed better association with prevalence of MetS, particularly in normal to mildly impaired GFR range. GFR(CKD-EPI) may improve risk stratification of individuals with MetS according to kidney function in community-based population.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Law and Bioethics (의료법윤리학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, So Yoon(김소윤) ORCID logo https://orcid.org/0000-0001-7015-357X
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Youn, Jong Chan(윤종찬)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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