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Sinus Augmentation Using BMP-2 in a Bovine Hydroxyapatite/Collagen Carrier in Dogs

Authors
 Jae-Kook Cha  ;  Jung-Seok Lee  ;  Min-Soo Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho  ;  Ui-Won Jung 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.41(1) : 86-93, 2014 
Journal Title
JOURNAL OF CLINICAL PERIODONTOLOGY
ISSN
 0303-6979 
Issue Date
2014
MeSH
Animals ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/therapeutic use* ; Cattle ; Collagen/chemistry* ; Dogs ; Durapatite/chemistry* ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/pathology ; Models, Animal ; Nasal Mucosa/diagnostic imaging ; Nasal Mucosa/pathology ; Organ Size ; Osteogenesis/drug effects ; Osteotomy/methods ; Radiography, Bitewing ; Sinus Floor Augmentation/methods* ; Surgical Flaps/surgery ; Tissue Scaffolds/chemistry ; X-Ray Microtomography/methods
Keywords
bone morphogenetic protein ; bone regeneration ; bone tissue engineering ; in vivo test ; scaffold
Abstract
AIM: The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model.
METHODS: Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses.
RESULTS: Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control.
CONCLUSION: BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12174/abstract
DOI
10.1111/jcpe.12174
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Soo(김민수)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97956
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