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Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Authors
 Jae-Hyun Lee  ;  Yong-Min Huh  ;  Jinwoo Cheon  ;  Jin-Suck Suh  ;  Ho-Geun Yoon  ;  Eun-Jin Cho  ;  Sungjun Kim  ;  Ho-Taek Song  ;  Jung-tak Jang  ;  Jung-wook Seo  ;  Young-wook Jun 
Citation
 Nature Medicine, Vol.13(1) : 95-99, 2007 
Journal Title
 Nature Medicine 
ISSN
 1078-8956 
Issue Date
2007
Abstract
Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
Full Text
http://www.nature.com/nm/journal/v13/n1/full/nm1467.html
DOI
10.1038/nm1467
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sungjun(김성준) ORCID logo https://orcid.org/0000-0002-7876-7901
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Cho, Eun Jin(조은진)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97172
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