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Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.

Authors
 Jin-Woo Kim ; Kyung-Hee Choi ; Kyoo-Sung Cho ; Seong-Ho Choi ; Chang-Sung Kim ; Ui-Won Jung ; Jeong-Ho Yun 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Vol.112(3) : 298~306, 2011 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 
ISSN
 1079-2104 
Issue Date
2011
Abstract
The objective of this study was to evaluate bone formation in rat calvarial defects after surgical implantation of block or particulated biphasic calcium phosphate (BCP) lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2). Critical-size calvarial osteotomy defects were created in 5 groups of Sprague-Dawley rats. Each group received one of the following: 1) sham surgery control; 2) biphasic calcium phosphate particles (CPP); 3) biphasic calcium phosphate block (CPB); 4) ErhBMP-2-coated CPP; or 5) ErhBMP-2-coated CPB. ErhBMP was coated on BCP by a stepwise lyophilizing protocol. The new bone formation was significantly greater in ErhBMP-2-treated groups compared with the untreated group. In particular, the ErhBMP-2/CPB group showed stability of augmented areas during the period of healing, due to relevant space-providing capacity. Thus, it can be concluded that CPP and CPB lyophilized with ErhBMP-2 enhance the formation of new bone, and CPB appears to be a suitable carrier for ErhBMP-2 in which a 3-dimensional structural integrity is an important consideration factor
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94329
DOI
10.1016/j.tripleo.2010.10.025
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Periodontology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1079210410008577
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