2 660

Cited 44 times in

Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.

Authors
 Jin-Woo Kim  ;  Kyung-Hee Choi  ;  Jeong-Ho Yun  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, Vol.112(3) : 298-306, 2011 
Journal Title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
ISSN
 1079-2104 
Issue Date
2011
MeSH
Animals ; BoneMorphogeneticProtein2/administration & dosage* ; BoneMorphogeneticProtein2/biosynthesis ; BoneRegeneration/drug effects* ; BoneRegeneration/physiology ; BoneSubstitutes/administration & dosage* ; BoneSubstitutes/chemistry ; Coated Materials, Biocompatible/administration & dosage* ; Coated Materials, Biocompatible/chemistry ; Drug Carriers ; Escherichiacoli ; Freeze Drying ; Humans ; Hydroxyapatites/administration & dosage* ; Hydroxyapatites/chemistry ; Male ; Osseointegration/drug effects ; Osseointegration/physiology ; Osteogenesis/drug effects ; Osteogenesis/physiology ; Particle Size ; ProteinEngineering/methods ; Rats ; Rats, Sprague-Dawley ; RecombinantProteins/biosynthesis ; Skull/anatomy & histology ; Skull/drug effects ; Skull/surgery ; Statistics, Nonparametric
Abstract
The objective of this study was to evaluate bone formation in rat calvarial defects after surgical implantation of block or particulated biphasic calcium phosphate (BCP) lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2). Critical-size calvarial osteotomy defects were created in 5 groups of Sprague-Dawley rats. Each group received one of the following: 1) sham surgery control; 2) biphasic calcium phosphate particles (CPP); 3) biphasic calcium phosphate block (CPB); 4) ErhBMP-2-coated CPP; or 5) ErhBMP-2-coated CPB. ErhBMP was coated on BCP by a stepwise lyophilizing protocol. The new bone formation was significantly greater in ErhBMP-2-treated groups compared with the untreated group. In particular, the ErhBMP-2/CPB group showed stability of augmented areas during the period of healing, due to relevant space-providing capacity. Thus, it can be concluded that CPP and CPB lyophilized with ErhBMP-2 enhance the formation of new bone, and CPB appears to be a suitable carrier for ErhBMP-2 in which a 3-dimensional structural integrity is an important consideration factor
Full Text
http://www.sciencedirect.com/science/article/pii/S1079210410008577
DOI
10.1016/j.tripleo.2010.10.025
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Yun, Jeong Ho(윤정호)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94329
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links