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Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.

Authors
 Jin-Woo Kim  ;  Kyung-Hee Choi  ;  Kyoo-Sung Cho  ;  Seong-Ho Choi  ;  Chang-Sung Kim  ;  Ui-Won Jung  ;  Jeong-Ho Yun 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Vol.112(3) : 298-306, 2011 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 
ISSN
 1079-2104 
Issue Date
2011
Abstract
The objective of this study was to evaluate bone formation in rat calvarial defects after surgical implantation of block or particulated biphasic calcium phosphate (BCP) lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2). Critical-size calvarial osteotomy defects were created in 5 groups of Sprague-Dawley rats. Each group received one of the following: 1) sham surgery control; 2) biphasic calcium phosphate particles (CPP); 3) biphasic calcium phosphate block (CPB); 4) ErhBMP-2-coated CPP; or 5) ErhBMP-2-coated CPB. ErhBMP was coated on BCP by a stepwise lyophilizing protocol. The new bone formation was significantly greater in ErhBMP-2-treated groups compared with the untreated group. In particular, the ErhBMP-2/CPB group showed stability of augmented areas during the period of healing, due to relevant space-providing capacity. Thus, it can be concluded that CPP and CPB lyophilized with ErhBMP-2 enhance the formation of new bone, and CPB appears to be a suitable carrier for ErhBMP-2 in which a 3-dimensional structural integrity is an important consideration factor
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94329
DOI
10.1016/j.tripleo.2010.10.025
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontology (치주과학교실)
Yonsei Authors
김창성(Kim, Chang Sung) ; 윤정호(Yun, Jeong Ho) ; 정의원(Jung, Ui Won) ; 조규성(Cho, Kyoo Sung) ; 최성호(Choi, Seong Ho)
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Full Text
http://www.sciencedirect.com/science/article/pii/S1079210410008577
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