Cited 44 times in
Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창성 | - |
dc.contributor.author | 윤정호 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2014-12-20T17:17:45Z | - |
dc.date.available | 2014-12-20T17:17:45Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1079-2104 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94329 | - |
dc.description.abstract | The objective of this study was to evaluate bone formation in rat calvarial defects after surgical implantation of block or particulated biphasic calcium phosphate (BCP) lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2). Critical-size calvarial osteotomy defects were created in 5 groups of Sprague-Dawley rats. Each group received one of the following: 1) sham surgery control; 2) biphasic calcium phosphate particles (CPP); 3) biphasic calcium phosphate block (CPB); 4) ErhBMP-2-coated CPP; or 5) ErhBMP-2-coated CPB. ErhBMP was coated on BCP by a stepwise lyophilizing protocol. The new bone formation was significantly greater in ErhBMP-2-treated groups compared with the untreated group. In particular, the ErhBMP-2/CPB group showed stability of augmented areas during the period of healing, due to relevant space-providing capacity. Thus, it can be concluded that CPP and CPB lyophilized with ErhBMP-2 enhance the formation of new bone, and CPB appears to be a suitable carrier for ErhBMP-2 in which a 3-dimensional structural integrity is an important consideration factor | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 298~306 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | BoneMorphogeneticProtein2/administration & dosage* | - |
dc.subject.MESH | BoneMorphogeneticProtein2/biosynthesis | - |
dc.subject.MESH | BoneRegeneration/drug effects* | - |
dc.subject.MESH | BoneRegeneration/physiology | - |
dc.subject.MESH | BoneSubstitutes/administration & dosage* | - |
dc.subject.MESH | BoneSubstitutes/chemistry | - |
dc.subject.MESH | Coated Materials, Biocompatible/administration & dosage* | - |
dc.subject.MESH | Coated Materials, Biocompatible/chemistry | - |
dc.subject.MESH | Drug Carriers | - |
dc.subject.MESH | Escherichiacoli | - |
dc.subject.MESH | Freeze Drying | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxyapatites/administration & dosage* | - |
dc.subject.MESH | Hydroxyapatites/chemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Osseointegration/drug effects | - |
dc.subject.MESH | Osseointegration/physiology | - |
dc.subject.MESH | Osteogenesis/drug effects | - |
dc.subject.MESH | Osteogenesis/physiology | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | ProteinEngineering/methods | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | RecombinantProteins/biosynthesis | - |
dc.subject.MESH | Skull/anatomy & histology | - |
dc.subject.MESH | Skull/drug effects | - |
dc.subject.MESH | Skull/surgery | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jin-Woo Kim | - |
dc.contributor.googleauthor | Kyung-Hee Choi | - |
dc.contributor.googleauthor | Jeong-Ho Yun | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.identifier.doi | 10.1016/j.tripleo.2010.10.025 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A02596 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J02443 | - |
dc.identifier.eissn | 1528-395X | - |
dc.identifier.pmid | 21292513 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1079210410008577 | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Yun, Jeong Ho | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Yun, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 112 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 298 | - |
dc.citation.endPage | 306 | - |
dc.identifier.bibliographicCitation | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, Vol.112(3) : 298-306, 2011 | - |
dc.identifier.rimsid | 27548 | - |
dc.type.rims | ART | - |
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