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Salvage chemotherapy of biweekly irinotecan plus S-1 (biweekly IRIS) in previously treated patients with advanced gastric cancer

Authors
 Hong Jae Chon  ;  Sun Young Rha  ;  Hei-Cheul Jeung  ;  Hyun Cheol Chung  ;  Sung Hoon Noh  ;  Jae Kyung Roh  ;  Hyo Song Kim  ;  Sang Joon Shin  ;  Hyung Soon Park 
Citation
 Cancer Chemotherapy and Pharmacology, Vol.68(4) : 991-999, 2011 
Journal Title
 Cancer Chemotherapy and Pharmacology 
ISSN
 0344-5704 
Issue Date
2011
Abstract
PURPOSE: This phase II trial first describes the combination chemotherapy of biweekly irinotecan plus S-1 (biweekly IRIS) for pretreated advanced gastric cancer (AGC) patients. METHODS: Patients who had previously been treated with greater than or equal to one regimen were enrolled. They received S-1 35 mg/m(2) twice daily on days 1-14 and irinotecan 150 mg/m(2) on days 1 and 15, every 4 weeks. The primary endpoint was overall survival (OS). RESULTS: Among the 38 patients enrolled, 18 patients were treated as second line, and the remaining 20 patients were enrolled as third- or fourth line. A total of 208 cycles were administered with the median being four cycles (range 1-16). The median OS was 8.7 months [95% confidence interval (CI) 7.5-10.3], and the median progression-free survival was 6.3 months (95% CI 5.3-7.3). Low serum albumin (<3.5 mg/dL) was an independent adverse prognosticator for survival. Overall response rate was 17% (95% CI 4-30%). The major grade 3/4 toxicities were neutropenia (26%) and diarrhea (18%). CONCLUSIONS: Biweekly IRIS showed the moderate activity as salvage treatment in AGC. Considering high neutropenia and gastrointestinal toxicity, patient selection should be warranted; serum albumin may be a predictive factor for treatment decision
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94058
DOI
10.1007/s00280-011-1560-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김효송(Kim, Hyo Song) ; 노성훈(Noh, Sung Hoon) ; 노재경(Roh, Jae Kyung) ; 라선영(Rha, Sun Young) ; 박형순(Park, Hyung Soon) ; 신상준(Shin, Sang Joon) ; 전홍재(Chon, Hong Jae) ; 정현철(Chung, Hyun Cheol) ; 정희철(Jeung, Hei Cheul)
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