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Effect of alendronate on healing of extraction sockets and healing around implants

 J-H Kim  ;  Y-B Park  ;  Z Li  ;  J-S Shim  ;  H-S Moon  ;  H-S Jung  ;  M-K Chung 
 Oral Diseases, Vol.17(7) : 705-711, 2011 
Journal Title
 Oral Diseases 
Issue Date
OBJECTIVES: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. MATERIALS AND METHODS: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0 mg kg(--1)) three times a week for 4 weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5 × 2.0 mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28 days following surgery. RESULTS: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7 days after extraction, and at 14 and 28 days after implantation. CONCLUSIONS: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
김지환(Kim, Jee Hwan) ORCID logo https://orcid.org/0000-0002-0872-4906
문홍석(Moon, Hong Seok) ORCID logo https://orcid.org/0000-0001-8118-8145
박영범(Park, Young Bum)
심준성(Shim, June Sung) ORCID logo https://orcid.org/0000-0003-1428-0122
정문규(Chung, Moon Kyu)
정한성(Jung, Han Sung)
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