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Effect of alendronate on healing of extraction sockets and healing around implants

DC FieldValueLanguage
dc.contributor.author김지환-
dc.contributor.author문홍석-
dc.contributor.author박영범-
dc.contributor.author심준성-
dc.contributor.author정문규-
dc.contributor.author정한성-
dc.date.accessioned2014-12-20T17:02:02Z-
dc.date.available2014-12-20T17:02:02Z-
dc.date.issued2011-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93835-
dc.description.abstractOBJECTIVES: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. MATERIALS AND METHODS: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0 mg kg(--1)) three times a week for 4 weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5 × 2.0 mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28 days following surgery. RESULTS: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7 days after extraction, and at 14 and 28 days after implantation. CONCLUSIONS: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets.-
dc.description.statementOfResponsibilityopen-
dc.format.extent705~711-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcid Phosphatase/analysis-
dc.subject.MESHAlendronate/pharmacology*-
dc.subject.MESHAlveolar Bone Loss/prevention & control-
dc.subject.MESHAnimals-
dc.subject.MESHAzo Compounds-
dc.subject.MESHBiomarkers/analysis-
dc.subject.MESHBone Density Conservation Agents/pharmacology*-
dc.subject.MESHCollagen Type I/analysis-
dc.subject.MESHColoring Agents-
dc.subject.MESHDental Implantation, Endosseous/instrumentation-
dc.subject.MESHDental Implants*-
dc.subject.MESHDental Materials/chemistry-
dc.subject.MESHEosine Yellowish-(YS)-
dc.subject.MESHIsoenzymes/analysis-
dc.subject.MESHMale-
dc.subject.MESHMaxilla/drug effects*-
dc.subject.MESHMaxilla/pathology-
dc.subject.MESHMethyl Green-
dc.subject.MESHMolar/surgery-
dc.subject.MESHOsseointegration/drug effects-
dc.subject.MESHOsteoclasts/pathology-
dc.subject.MESHOsteogenesis/drug effects-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHTartrate-Resistant Acid Phosphatase-
dc.subject.MESHTime Factors-
dc.subject.MESHTitanium/chemistry-
dc.subject.MESHTooth Extraction-
dc.subject.MESHTooth Socket/drug effects*-
dc.subject.MESHTooth Socket/pathology-
dc.subject.MESHWound Healing/drug effects-
dc.titleEffect of alendronate on healing of extraction sockets and healing around implants-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorJ-H Kim-
dc.contributor.googleauthorY-B Park-
dc.contributor.googleauthorZ Li-
dc.contributor.googleauthorJ-S Shim-
dc.contributor.googleauthorH-S Moon-
dc.contributor.googleauthorH-S Jung-
dc.contributor.googleauthorM-K Chung-
dc.identifier.doi10.1111/j.1601-0825.2011.01829.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01006-
dc.contributor.localIdA01395-
dc.contributor.localIdA01567-
dc.contributor.localIdA02211-
dc.contributor.localIdA03600-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid21771209-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01829.x/abstract-
dc.contributor.alternativeNameKim, Jee Hwan-
dc.contributor.alternativeNameMoon, Hong Seok-
dc.contributor.alternativeNamePark, Young Bum-
dc.contributor.alternativeNameShim, June Sung-
dc.contributor.alternativeNameChung, Moon Kyu-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorKim, Jee Hwan-
dc.contributor.affiliatedAuthorMoon, Hong Seok-
dc.contributor.affiliatedAuthorPark, Young Bum-
dc.contributor.affiliatedAuthorShim, June Sung-
dc.contributor.affiliatedAuthorChung, Moon Kyu-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.rights.accessRightsnot free-
dc.citation.volume17-
dc.citation.number7-
dc.citation.startPage705-
dc.citation.endPage711-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.17(7) : 705-711, 2011-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers

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