Cited 25 times in
Effect of alendronate on healing of extraction sockets and healing around implants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지환 | - |
dc.contributor.author | 문홍석 | - |
dc.contributor.author | 박영범 | - |
dc.contributor.author | 심준성 | - |
dc.contributor.author | 정문규 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2014-12-20T17:02:02Z | - |
dc.date.available | 2014-12-20T17:02:02Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93835 | - |
dc.description.abstract | OBJECTIVES: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. MATERIALS AND METHODS: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0 mg kg(--1)) three times a week for 4 weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5 × 2.0 mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28 days following surgery. RESULTS: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7 days after extraction, and at 14 and 28 days after implantation. CONCLUSIONS: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 705~711 | - |
dc.relation.isPartOf | ORAL DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acid Phosphatase/analysis | - |
dc.subject.MESH | Alendronate/pharmacology* | - |
dc.subject.MESH | Alveolar Bone Loss/prevention & control | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Azo Compounds | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | Bone Density Conservation Agents/pharmacology* | - |
dc.subject.MESH | Collagen Type I/analysis | - |
dc.subject.MESH | Coloring Agents | - |
dc.subject.MESH | Dental Implantation, Endosseous/instrumentation | - |
dc.subject.MESH | Dental Implants* | - |
dc.subject.MESH | Dental Materials/chemistry | - |
dc.subject.MESH | Eosine Yellowish-(YS) | - |
dc.subject.MESH | Isoenzymes/analysis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maxilla/drug effects* | - |
dc.subject.MESH | Maxilla/pathology | - |
dc.subject.MESH | Methyl Green | - |
dc.subject.MESH | Molar/surgery | - |
dc.subject.MESH | Osseointegration/drug effects | - |
dc.subject.MESH | Osteoclasts/pathology | - |
dc.subject.MESH | Osteogenesis/drug effects | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Tartrate-Resistant Acid Phosphatase | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Titanium/chemistry | - |
dc.subject.MESH | Tooth Extraction | - |
dc.subject.MESH | Tooth Socket/drug effects* | - |
dc.subject.MESH | Tooth Socket/pathology | - |
dc.subject.MESH | Wound Healing/drug effects | - |
dc.title | Effect of alendronate on healing of extraction sockets and healing around implants | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | J-H Kim | - |
dc.contributor.googleauthor | Y-B Park | - |
dc.contributor.googleauthor | Z Li | - |
dc.contributor.googleauthor | J-S Shim | - |
dc.contributor.googleauthor | H-S Moon | - |
dc.contributor.googleauthor | H-S Jung | - |
dc.contributor.googleauthor | M-K Chung | - |
dc.identifier.doi | 10.1111/j.1601-0825.2011.01829.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01006 | - |
dc.contributor.localId | A01395 | - |
dc.contributor.localId | A01567 | - |
dc.contributor.localId | A02211 | - |
dc.contributor.localId | A03600 | - |
dc.contributor.localId | A03758 | - |
dc.relation.journalcode | J02438 | - |
dc.identifier.eissn | 1601-0825 | - |
dc.identifier.pmid | 21771209 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01829.x/abstract | - |
dc.contributor.alternativeName | Kim, Jee Hwan | - |
dc.contributor.alternativeName | Moon, Hong Seok | - |
dc.contributor.alternativeName | Park, Young Bum | - |
dc.contributor.alternativeName | Shim, June Sung | - |
dc.contributor.alternativeName | Chung, Moon Kyu | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hwan | - |
dc.contributor.affiliatedAuthor | Moon, Hong Seok | - |
dc.contributor.affiliatedAuthor | Park, Young Bum | - |
dc.contributor.affiliatedAuthor | Shim, June Sung | - |
dc.contributor.affiliatedAuthor | Chung, Moon Kyu | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 705 | - |
dc.citation.endPage | 711 | - |
dc.identifier.bibliographicCitation | ORAL DISEASES, Vol.17(7) : 705-711, 2011 | - |
dc.identifier.rimsid | 28495 | - |
dc.type.rims | ART | - |
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