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Gadoxetate disodium-enhanced magnetic resonance imaging versus contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of colorectal liver metastases

 Hyo Jung Seo  ;  Myeong-Jin Kim  ;  Jong Doo Lee  ;  Woo-Suk Chung  ;  Yeo-Eun Kim 
 INVESTIGATIVE RADIOLOGY, Vol.46(9) : 548-555, 2011 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/diagnosis* ; Colorectal Neoplasms/pathology ; Contrast Media* ; Female ; Fluorodeoxyglucose F18 ; Gadolinium DTPA* ; Humans ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/secondary ; Magnetic Resonance Imaging/instrumentation* ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Positron-Emission Tomography/instrumentation* ; Positron-Emission Tomography/methods ; Predictive Value of Tests ; ROC Curve ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Statistics as Topic ; Tomography, X-Ray Computed/instrumentation ; Tomography, X-Ray Computed/methods
liver ; metastases ; gadoxetate disodium-enhanced MRI ; contrast-enhanced PET/CT
PURPOSE: : To compare the diagnostic accuracy of gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI) on a 3-T system and integrated contrast-enhanced F-fluorodeoxyglucose positron emission tomography/computed tomography (CE-PET/CT) for the detection of hepatic metastases from colorectal cancers.

MATERIALS AND METHODS: : The approval from the institutional review board was obtained, and the requirement for informed consent was waived. We retrospectively evaluated 135 metastases in 68 patients (37 men, 31 women; mean age: 68 years; age range: 37-82 years) who underwent both EOB-MRI and CE-PET/CT. A total of 103 metastases were confirmed during surgery and 32 were confirmed by imaging findings during follow-up. The images were independently reviewed by 2 observers. The diagnostic accuracies of EOB-MRI and CE-PET/CT were determined by calculating the areas under each reader-specific receiver operating characteristic curve (Az). Patient-based lesion sensitivity and specificity were compared using the McNemar test.

RESULTS: : The mean area under the Az on EOB-MRI versus CE-PET/CT was 0.94 versus 0.81 for all lesions (P < 0.001), 0.92 versus 0.60 for lesions ≤1 cm in size (P < 0.001), and 0.88 versus 0.96 for lesions >1 cm (P = 0.098), respectively. The sensitivity, specificity, positive predictive values, and negative predictive value on a patient basis were 100%, 71%, 97%, and 100% for EOB-MRI and 93%, 71%, 97%, and 57% for CE-PET/CT, respectively.

CONCLUSIONS: : EOB-MRI using a 3-T system is more accurate than CE-PET/CT, especially for the detection of small (≤1.0 cm) lesions. Patient-based analysis revealed that EOB-MRI has a higher sensitivity and negative predictive value than CE-PET/CT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yoo, Sun Kook(유선국) ORCID logo https://orcid.org/0000-0002-6032-4686
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
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