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¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure

Authors
 Seok-Min Kang  ;  Jong-Chul Park  ;  Min-Jeong Shin  ;  Hyeran Lee  ;  Jaewon Oh  ;  Do Hyun Ryu  ;  Geum-Sook Hwang  ;  Ji Hyung Chung 
Citation
 CLINICAL BIOCHEMISTRY, Vol.44(4) : 293-299, 2011 
Journal Title
 CLINICAL BIOCHEMISTRY 
ISSN
 0009-9120 
Issue Date
2011
MeSH
Acetic Acid/urine ; Acetone/urine ; Aged ; Case-Control Studies ; Cytosine/urine ; Energy Metabolism* ; Female ; Glycine/analogs & derivatives ; Glycine/urine ; Heart Failure, Systolic/physiopathology ; Heart Failure, Systolic/urine* ; Humans ; Male ; Metabolome ; Metabolomics ; Methylmalonic Acid/urine ; Multivariate Analysis ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/urine* ; Niacinamide/analogs & derivatives ; Niacinamide/urine ; Nuclear Magnetic Resonance, Biomolecular ; Protons ; Urinalysis/methods*
Keywords
Heart failure ; Citric acid cycle ; Metabolism ; Methylmalonic acid ; Phenylacetylglycine
Abstract
OBJECTIVES: We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. DESIGN AND METHODS: Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with type 2 diabetes mellitus were excluded. RESULTS: The results showed that the urine of the HF patients had higher levels of metabolites for acetate (p<0.05) and acetone (p<0.01) compared to the healthy controls. In addition, there was a perturbation in methylmalonate metabolism as shown by increased urinary levels of methylmalonic acid (p<0.001) in the HF patients. HF patients also had increased urinary levels of cytosine (p<0.01) and phenylacetylglycine (p<0.01) and decreased 1-methylnicotinamide (p<0.05) compared to healthy controls. CONCLUSIONS: TCA cycle metabolites and fatty acid metabolism were modified in the HF patients, indicating altered energy metabolism. Moreover, perturbations of metabolism in nucleotide and methylmalonate were observed.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009912010005114
DOI
10.1016/j.clinbiochem.2010.11.010
Appears in Collections:
5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Chung, Ji Hyung(정지형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92621
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