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¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure

Authors
 Seok-Min Kang ; Jong-Chul Park ; Ji Hyung Chung ; Geum-Sook Hwang ; Do Hyun Ryu ; Jaewon Oh ; Hyeran Lee ; Min-Jeong Shin 
Citation
 Clinical Biochemistry, Vol.44(4) : 293~299, 2011 
Journal Title
 Clinical Biochemistry 
ISSN
 0009-9120 
Issue Date
2011
Abstract
OBJECTIVES: We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. DESIGN AND METHODS: Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with type 2 diabetes mellitus were excluded. RESULTS: The results showed that the urine of the HF patients had higher levels of metabolites for acetate (p<0.05) and acetone (p<0.01) compared to the healthy controls. In addition, there was a perturbation in methylmalonate metabolism as shown by increased urinary levels of methylmalonic acid (p<0.001) in the HF patients. HF patients also had increased urinary levels of cytosine (p<0.01) and phenylacetylglycine (p<0.01) and decreased 1-methylnicotinamide (p<0.05) compared to healthy controls. CONCLUSIONS: TCA cycle metabolites and fatty acid metabolism were modified in the HF patients, indicating altered energy metabolism. Moreover, perturbations of metabolism in nucleotide and methylmalonate were observed.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92621
DOI
10.1016/j.clinbiochem.2010.11.010
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Cardiovascular Product Evaluation Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0009912010005114
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